Experimental Medicine and Biology Institute

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial i...

Neuropathological Effects of Early Maternal Separation are Prevented by CORT113176, A Glucocorticoid Receptor Modulator

Early-life stress, such as maternal separation (MS), disrupts the pup´s hypothalamic–pituitary–adrenal (HPA) axis and causes neuropathological changes in several nervous system regions, including the spinal cord. This damage is driven by glucocorticoid receptor (GR) overactivatio...