Experimental Medicine and Biology Institute

Altered IRE1α-Dependent Decidual Programming Links Impaired Inflammation and Angiogenesis in Recurrent Implantation Failure

Background: Decidualization alters the endometrial stromal cells (EnSC) secretome, allowing sterile inflammation associated with embryo implantation, but mechanisms that lead to alterations in this process are still unknown. We evaluated whether impaired IRE1α-mediated endoplasmi...

Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features

Background: Adipose tissue (AT) has emerged as a metabolically active component of the breast tumor microenvironment that contributes to breast cancer (BC) progression. Adipocytes release adipokines and lipids that influence tumor growth; however, the specific lipolytic proteins...

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial i...

Neuropathological Effects of Early Maternal Separation are Prevented by CORT113176, A Glucocorticoid Receptor Modulator

Early-life stress, such as maternal separation (MS), disrupts the pup´s hypothalamic–pituitary–adrenal (HPA) axis and causes neuropathological changes in several nervous system regions, including the spinal cord. This damage is driven by glucocorticoid receptor (GR) overactivatio...