European University Cyprus

Decoupling T cell cytotoxicity: a CCL21+ICAM1-based synthetic immune niche enhances tumor elimination by accelerating lytic hit delivery

Preserving T cell cytotoxic function during ex vivo expansion remains a major challenge for adoptive cancer immunotherapy. A synthetic immune niche (SIN) composed of immobilized CCL21 and ICAM1 was shown to improve T cell expansion while preserving cytotoxicity; however, it remai...

Breaking the Blend: A multi-tracer kinematic decomposition method for IFS data applied to disentangling the AGN outflow and circumnuclear ring in NGC 5728 with JWST

Abstract Integral field spectroscopy (IFS) of the central kiloparsecs of active galactic nuclei (AGN) reveals a mixture of spatially coincident emission from star-formation and AGN feedback exciting the interstellar medium. Disentangling these components remains a challenge, as m...

The robotic PIANO: a critical narrative review of surgeon-controlled operative polyphony, human factors, and robotic training

Abstract Robotic surgery can concentrate control of several technical functions at the console, but such concentration does not itself confer clinical independence, reduce dependence on the perioperative team, or improve patient outcomes. We define surgeon-controlled operative po...

Integrated Molecular, Clinicopathological and Immune Profiling of Non-Small Cell Lung Cancer: The MONREPOS Hellenic Cooperative Oncology Group (HeCOG) Study (HE_2TR/13)

Integrated assessment of tumour genomics and immune biomarkers may improve prognostic stratification in non-small cell lung cancer (NSCLC). We examined the distribution and prognostic relevance of somatic pathogenic/likely pathogenic variants (PVs), somatic copy-number alteration...

Lipoprotein and apolipoprotein levels in age-related macular degeneration: A meta-analysis

Purpose Drusen, the hallmark of AMD, are lipoprotein-rich particles. However, the role of systemic lipid metabolism in their formation remains controversial. This meta-analysis explored the association between ApoA1, ApoA2, ApoB and Lp(a) serum levels and AMD. Methods We systemat...

The Gravitational-wave Optical Transient Observer (GOTO) Fast Analysis and Spectroscopy of Transients (FAST) Surveys

Abstract The study of young and fast astronomical transients is often limited by the difficulty of acquiring data, particularly spectra, within hours to days of explosion. Historically, follow-up programmes have rarely obtained spectra until many days after discovery; coupled wit...

Effects of suspension training and bodyweight resistance training on neuromuscular power, sprint, and agility performance in untrained male adolescents: a three-arm randomized controlled trial

This study compared suspension training (ST) and bodyweight resistance training (RT) with a control condition (CON) for physical performance in untrained male adolescents. Seventy-two participants (age 14.74 ± 0.32 years) were randomized equally to ST, RT, or CON. One participant...

Celiac Disease Management in School Environments: An Interdisciplinary Narrative Review of Operational, Psychosocial, and Nutritional Barriers

Background: Pediatric celiac disease (CD) prevalence is rising, estimated at 2% to 3% in select screening cohorts. Affected children face significant environmental, psychosocial, and nutritional barriers within institutional school settings. Methods: This narrative review synthes...

Balloon-Expandable Versus Self-Expandable Transcatheter Aortic Valve Implantation Devices: A Contemporary Systematic Review

Background/Objectives: Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Prosthesis selection is increasingly important because balloon-expandable valves (BEVs) and self-expandable valves (SEVs) differ in deployment, hemodynami...

The relationship between personality traits and test anxiety in adolescents: The mediating role of academic hardiness

Recent evidence suggests that test anxiety is widespread among adolescents and associated with adverse academic and psychological outcomes. While the relationship between personality traits and test anxiety is documented, limited research has examined the underlying resilience me...

HAT1 regulates glioblastoma cell proliferation and membrane lipid remodeling through ALDH2

Abstract Glioblastoma (GBM) is the most aggressive and lethal form of primary brain cancer in adults, characterized by rapid cell proliferation, resistance to therapy, and poor patient outcomes. While epigenetic dysregulation is increasingly recognized in glioma pathogenesis, the...

MXene-based biosensors for hospital-on-chip diagnostics: a coordination chemistry framework from materials design to clinical translation

MXenes, a rapidly expanding family of two-dimensional transition metal carbides and nitrides, have emerged as promising materials for hospital-on-chip (HoC) diagnostics because of their high electrical conductivity, chemically tunable surfaces, and versatile biofunctionalization....

Oral Pemphigus in Children and Adolescents: A Narrative Review of Published Case Reports

Background: Pemphigus is a rare group of autoimmune blistering diseases characterized by autoantibody-mediated loss of keratinocyte adhesion, resulting in intraepithelial blister formation involving the skin and mucous membranes. Pemphigus Vulgaris (PV) is the most common type of...

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study in...

Integrating Instagram into anatomy and histology education: A comprehensive review of current evidence and pedagogical outcomes

Purpose Instagram is a highly popular social media platform, which has been implemented as a teaching modality of several disciplines. We performed a literature review of its use for anatomy and histology teaching, given the lack of reviews with this purpose. Methods We searched...

Climate Change Impacts on One Health Systems: A Narrative Review of Empirical Evidence and Policy Responses

ABSTRACT Background Climate change poses critical threats to human, animal, and environmental health, yet evidence on integrated One Health responses remains fragmented. Although numerous studies highlight climate‐driven health risks, many climate adaptation frameworks still unde...

Effects of Proprioceptive Neuromuscular Facilitation-Based Reformer Pilates and Hatha Yoga on Functional Fitness, Balance, and Cognitive Performance in Older Women: A 16-Week Randomized Controlled Trial

Abstract Background Aging is associated with progressive declines in neuromuscular function, postural control, and cognitive performance, which may compromise functional independence. Mind–body exercise approaches such as Pilates and Yoga have been suggested as effective strategi...

Healthcare providers’ perspectives on physical activity in patients with heart failure and gender-related differences.

Objectives Physical activity (PA) is widely recognized as an effective intervention for patients with heart failure (HF). PA leads to significant improvements in outcomes such as aerobic capacity, quality of life, and cardiac function, which are linked to reduced hospitalizations...

Highly suppressed tensor-to-scalar ratio from a modified Lennard–Jones inflationary potential

Abstract The increasingly stringent observational bounds on primordial gravitational waves strongly constrain inflationary model building, favoring scenarios that predict highly suppressed tensor perturbations. While many viable constructions rely on non-canonical kinetic terms,...