European Telecommunications Standards Institute

Computational Assessment of CKP-25 Binding at Receptor-Recognition Interfaces Across Diverse Human Coronaviruses

Background/Objectives: The continued emergence of novel coronaviruses motivates the search for small molecules that bind conserved features of the spike receptor-recognition interface across diverse species. CKP-25 was recently reported as a small-molecule inhibitor of the SARS-C...

Gamified IMU Sensor-Based System for Training Head-Orientation Tasks in Healthy Teenagers: Event-Driven Architecture and Randomised Pilot Feasibility Study

Sensor systems integrated with gamified environments have increasingly been incorporated into the monitoring of musculoskeletal disorders. This study evaluates the operational feasibility of a motion-capture system based on an inertial measurement unit for training head-orientati...

Multiuser immersive cultural experiences enabled by 5G, AI and free-viewpoint video

Extended Reality (XR) enhances cultural experiences by immersing users in virtual environments where virtual assets and 3D reconstructions provide a stronger connection to real-world scenarios. In this work, we present a platform for collaborative immersive cultural experiences,...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Volume Electron Microscopy of Cortical Organoids: Methods for Region Identification, Connectome Reconstruction, and Organelle Segmentation

Abstract Volume electron microscopy (vEM) has become a powerful tool for 3D ultrastructural analysis of neural circuits, yet its application to human brain organoids remains limited, particularly for connectomic studies. Here, we established a comprehensive and scalable workflow...

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune in...