Institution
European Molecular Biology Laboratory
Recent research
- BiologyOpen access
Eukaryotic cells are spatially organized into functionally-distinct compartments. This three-dimensional (3D) organization generates intracellular heterogeneities that can modulate regulatory dynamics. Despite this knowledge of subcellular organization, most quantitative gene-reg...
- AI & ComputingOpen access
Federated EGA in the European and Global Human Data Ecosystem
This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...
- BiologyOpen access
ABSTRACT De novo protein design often produces thermostable proteins that denature above 100 °C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical and thermal denaturation followed by global analysis of multiple melting...
- BiologyOpen access
Clathrin adaptors drive phase separation in endocytosis and trafficking
Abstract Liquid–liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize processes, including endocytosis and membrane trafficking. Although LLPS has been implicated in clathrin-mediated pathways, the contribution of adaptor proteins to con...
- BiologyOpen access
A cross-species atlas platform for comparative neuroscience in teleost fish
Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...
- BiologyOpen access
The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics
Abstract The shape of animal cells is controlled by their surface, which comprises the cell cortex, a peripheral actin network, tethered to the plasma membrane by membrane-to-cortex attachment proteins. Changes in cortical components have long been considered to dominate the regu...