Institution
European Molecular Biology Laboratory
Recent research
- Health & MedicineOpen access
Decoding the regulatory programs governing glioblastoma plasticity
Abstract Glioblastoma is incurable and resistant to therapy despite genomic stability under treatment 1–8 , suggesting that non-genetic cellular plasticity is a central driver of progression. Whether such plasticity reflects stochastic state switching or is governed by predictabl...
- BiologyOpen access
A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity
Abstract Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single...
- BiologyOpen access
Abstract Rho-associated protein kinases (ROCK1/2) are critical regulators of fundamental cellular processes and represent promising therapeutic targets for various pathologies, particularly cardiovascular disease. While the terminal globular kinase domain and the PH-C1 tandem (PH...
- BiologyOpen access
The limits of scaling in aggregation-driven patterning of cell collectives
Abstract Robust development requires maintaining correct proportions as overall size varies. What controls and limits this scaling remains poorly understood due to the complex interplay of mechanical and biochemical embryonic factors. Combining confinement of dissociated embryoni...
- AI & ComputingOpen access
Federated EGA in the European and Global Human Data Ecosystem
This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...
- BiologyOpen access
Eukaryotic cells are spatially organized into functionally-distinct compartments. This three-dimensional (3D) organization generates intracellular heterogeneities that can modulate regulatory dynamics. Despite this knowledge of subcellular organization, most quantitative gene-reg...
- BiologyOpen access
Clathrin adaptors drive phase separation in endocytosis and trafficking
Abstract Liquid–liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize processes, including endocytosis and membrane trafficking. Although LLPS has been implicated in clathrin-mediated pathways, the contribution of adaptor proteins to con...
- BiologyOpen access
A cross-species atlas platform for comparative neuroscience in teleost fish
Abstract Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structure...
- Health & MedicineOpen access
Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency
Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...
- AI & ComputingOpen access
Source-Free Domain Adaptation with Vision-Language Prior
Abstract Source-Free Domain Adaptation (SFDA) seeks to adapt a source model, which is pre-trained on a supervised source domain, for a target domain, with only access to unlabeled target training data. Relying on pseudo labeling and/or auxiliary supervision, conventional methods...
- BiologyOpen access
Plasma membrane order maps functional diversity in immune cells
Abstract Cell membranes undergo biophysical remodeling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune cells remain unknown, largely because of the lack of single-cell and multidi...
- BiologyOpen access
Abstract SnoRNAs are highly expressed in AML and have implications in leukemogenesis and leukemic maintenance. SnoRNAs can be further processed into snoRNA-derived RNAs (sdRNAs). The role of sdRNAs in AML and healthy hematopoiesis remains largely elusive. We characterized sdRNA a...
- Health & MedicineOpen access
Background: Myelodysplastic neoplasms (MDSs) are clonal hematopoietic stem cell disorders associated with ineffective hematopoiesis, chronic inflammation, and increased cardiovascular morbidity. Although metabolic dysregulation has been implicated in MDS pathogenesis, systemic me...
- Climate & Environment
Appendages are key features of the body plans of arthropods and vertebrates, yet little is known about appendage formation outside of bilaterians. Here, we investigate the molecular regulation underlying the formation of tentacles, the appendages in cnidarians. We find that the b...
- Health & MedicineOpen access
Abstract ASTRACT Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking....