Institution
European Molecular Biology Laboratory
Recent research
- AI & ComputingOpen access
Source-Free Domain Adaptation with Vision-Language Prior
Abstract Source-Free Domain Adaptation (SFDA) seeks to adapt a source model, which is pre-trained on a supervised source domain, for a target domain, with only access to unlabeled target training data. Relying on pseudo labeling and/or auxiliary supervision, conventional methods...
- BiologyOpen access
Plasma membrane order maps functional diversity in immune cells
Abstract Cell membranes undergo biophysical remodeling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune cells remain unknown, largely because of the lack of single-cell and multidi...
- BiologyOpen access
Abstract SnoRNAs are highly expressed in AML and have implications in leukemogenesis and leukemic maintenance. SnoRNAs can be further processed into snoRNA-derived RNAs (sdRNAs). The role of sdRNAs in AML and healthy hematopoiesis remains largely elusive. We characterized sdRNA a...
- Health & MedicineOpen access
Background: Myelodysplastic neoplasms (MDSs) are clonal hematopoietic stem cell disorders associated with ineffective hematopoiesis, chronic inflammation, and increased cardiovascular morbidity. Although metabolic dysregulation has been implicated in MDS pathogenesis, systemic me...
- Climate & Environment
Appendages are key features of the body plans of arthropods and vertebrates, yet little is known about appendage formation outside of bilaterians. Here, we investigate the molecular regulation underlying the formation of tentacles, the appendages in cnidarians. We find that the b...
- Health & MedicineOpen access
Abstract ASTRACT Background Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) demonstrates clinical efficacy in metastatic castration-resistant prostate cancer (mCRPC), yet robust biomarkers for dynamic treatment monitoring and resistance remain lacking....