European Molecular Biology Laboratory

Federated EGA in the European and Global Human Data Ecosystem

This Federated EGA in the European and Global Human Data Ecosystem white paper sets out our vision for the future role of Federated EGA (FEGA) in supporting secure, responsible and FAIR reuse of controlled-access human data. It describes how FEGA has developed into an operational...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...