Estée Lauder (United States)

A proposed evaluation of new approach methodologies for dermal toxicity assessment of botanicals

Background Botanicals are widely used in topical formulations for cosmetics, hair care, and personal care products, reflecting consumer interest in plant-derived materials. Their complex and variable composition, presents challenges for traditional toxicological approaches develo...

Experimental and computational investigation of collagen modification in skin chromatic alterations

Skin darkening and yellowing are significant concerns associated with aging, particularly among Asian women. Skin sallowness in aging is influenced by factors such as melanin deposition, dermal glycation, and carbonylation, which alter skin’s optical properties. However, the mech...