Eskişehir City Hospital

Fetal adrenal microvascular index and adrenal volume in late‐onset fetal growth restriction: A prospective observational study

Abstract Objective This study evaluates the fetal adrenal gland microvascular index (MVI) and adrenal volume in late‐onset fetal growth restriction (FGR) using MV‐Flow and three‐dimensional Extended Imaging Virtual Organ Computer‐Aided Analysis and assesses their associations wit...

Postmortem Gene Expression and the Thanatotranscriptome: Postmortem Interval Estimation, Forensic Applications, and Future Perspectives

Postmortem molecular changes are more complex than a passive, uniform cessation of all cellular activity. Human and animal studies have demonstrated that certain RNA transcripts remain detectable for defined periods after death and that transcript levels exhibit tissue- and time-...

Association of left atrioventricular coupling index with mortality in heart failure with preserved ejection fraction

Background The left atrioventricular coupling index (LACI) is a novel echocardiographic parameter reflecting atrioventricular interaction and cardiac remodelling. However, its association with mortality in heart failure with preserved ejection fraction (HFpEF) remains unclear. We...

Artificial Intelligence in Echocardiography: Five Clinical Challenges and a Roadmap Toward Responsible Integration by 2030

Artificial intelligence (AI)-enabled echocardiography has demonstrated strong agreement with expert measurements across a broad range of cardiac functional parameters. However, the transition from technical validation to clinical impact remains incomplete. This structured narrati...

Patient Expectations, Satisfaction and Perceptions of Specialization in Family Medicine: A Cross-Sectional Study from a Health Literacy Perspective in Türkiye

Background/Objectives: Patient expectations, satisfaction, and perceptions of specialization in family medicine are critical to improving primary care, and health literacy (HL) shapes patients’ engagement with health information. This study assessed these domains and their relati...

Design, Synthesis, and X-ray Characterization of Benzohydrazide Derivatives as Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: An Experimental and Computational Approach to Biological Activity

In this study, a series of new benzohydrazide derivatives (1a-i) were synthesized, and characterized as potential cholinesterase inhibitors for use in the treatment of Alzheimer’s disease (AD). The inhibitory activities of the synthesized compounds against acetylcholinesterase (A...

SOX17 and TRPS1 in Müllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions

Background Malignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing Müllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because o...

Rejection Sensitivity Among Adults with Comorbid Borderline Personality Disorder and Attention-Deficit/Hyperactivity Disorder

Background: Rejection sensitivity (RS)—anxious expectations of interpersonal rejection—is consistently elevated in borderline personality disorder (BPD), but evidence in attention-deficit/hyperactivity disorder (ADHD), particularly in adults, remains limited and mixed. We compare...

Preliminary evaluation of a large language model for pediatric uroflowmetry interpretation: a single-center comparative analysis with local expert consensus

This study aimed to evaluate the performance of a large language model (LLM)-based artificial intelligence system in interpreting pediatric uroflowmetry (UFM) results using both conceptual knowledge and real-world clinical data. This retrospectively designed study involved a two-...

Prognostic value of HALP score, Prognostic Nutritional Index (PNI), and Lymph Node Ratio (LNR) in right-sided colon adenocarcinoma: a retrospective single-center cohort analysis with clinico-pathological correlations

Abstract Introduction Preoperative systemic immunonutritional indices offer cost-effective, host-centric prognostic insights. This study evaluated the independent long-term prognostic utility of the Prognostic Nutritional Index (PNI), Hemoglobin–Albumin–Lymphocyte–Platelet (HALP)...

Synthesis of Quinazoline Derivatives and Mechanistic Approaches in Lung and Breast Cancers

The quinazoline/quinazolinone ring is known as a unique scaffold, and its derivatives possess a broad biological activity profile, including antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, and analgesic activity, primarily focusing on anticancer activity....

Clinical Impact of Fingolimod-Associated Lymphopenia in Multiple Sclerosis: A Real-World Cohort Study

Background and Objectives: Fingolimod, a sphingosine-1-phosphate receptor modulator, is an effective disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Although lymphopenia is a well-recognized pharmacological effect, its clinical significance remains uncer...

Comparative Lipophilic Phytochemical Profiling and Bioactivity Assessment of Different Organs of Mahonia aquifolium (Pursh) Nutt.: Integrated Analysis of n-Hexane Extracts, Essential Oils and Fatty Acids

Mahonia aquifolium (Pursh) Nutt. is a medicinal plant known for its diverse phytochemical composition; however, information on the lipophilic constituents of its different organs remains limited. This study aimed to characterize the lipophilic composition and associated bioactivi...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Assessment of social distance toward refugees and related factors among prehospital emergency health care providers

Objective: Social distance towards refugees among health care providers reflects how refugees benefit from health services and empathy, acceptance, and discrimination. Social distance is crucial for Pre-Hospital Emergency Health Care Providers (PHEHCP), who are the first group to...

Investigating the relationships between gender inequality, international trade and innovation: evidence from Türkiye

This study examines the complex relationships between gender inequality, international trade, and innovation in Türkiye. Gender inequality, international trade, and innovation data, compiled for the Turkish economy between 1991 and 2022, were analyzed using the Nonlinear Autoregr...

Association of Anatomical Localization with Early Recurrence After Premature Ventricular Contraction Ablation

To evaluate the association of anatomical localization with early recurrence during 24-hour telemetry among patients achieving acute electrophysiology laboratory (EP-lab) success, and secondarily with acute EP-lab outcome and target PVC detection in the overall cohort. This retro...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...