Erzurum Regional Training and Research Hospital

Annona muricata Leaf Extract Rebalances Systemic Redox Status and Modulates Neuroimmune, Microbial, and Functional Responses in CLP-Induced Septic Rats

Oxidative stress, immune dysregulation, and disturbed metabolic adaptation contribute to early sepsis pathophysiology. This exploratory study evaluated a commercial Annona muricata leaf extract in 40 male rats assigned to five groups (n = 8/group): healthy Control, laparotomy-onl...

Stage-dependent alterations in MaR1 in pediatric chronic kidney disease: a potential candidate biomarker

Chronic kidney disease (CKD) in children is characterized by persistent inflammation and oxidative stress, contributing to progressive loss of renal function and multisystem involvement. Maresin 1 (MaR1), a specialized pro-resolving lipid mediator derived from docosahexaenoic aci...

Protective effects of flunarizine and ATP against pembrolizumab-associated gastric injury in rats

Abstract Pembrolizumab, an immune checkpoint inhibitor targeting pro-grammed cell death protein-1 (PD-1), is widely used in cancer therapy. However, its potential gastrotoxic effects and underlying molecular mechanisms remain poorly understood. Flunarizine has antioxidant, calciu...

Association of admission serum copeptin with hemorrhagic shock severity in adult trauma patients

Abstract Hemorrhagic shock remains a major cause of potentially preventable death after trauma, and early assessment of its severity is essential. This prospective observational biomarker study evaluated admission serum copeptin in 103 adult trauma patients. The primary analysis...

Microbiological monitoring of scuba cylinders under routine filling and seasonal diving conditions

Introduction: The aim of this study was to monitor the microbiological status of the inner surfaces of scuba cylinders under routine air filling conditions and to assess whether microbiological contamination emerges or persists over time. Methods: A prospective longitudinal micro...

Evaluation of Dermatologists’ Opinions in the Face of Increasing Scabies Cases: A Survey Study

Objective: Scabies is a common and highly contagious parasitic skin disease that continues to pose a significant public health burden worldwide and in Türkiye. This study aimed to evaluate the approaches, experiences, and challenges of dermatologists in Türkiye regarding the diag...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...