Erasmus MC Transplant Institute

Predictive Value of Perfusate Cell-free DNA During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys.

Background: Cell-free DNA (cfDNA) is a potential biomarker for graft (dys)function during machine perfusion, but its ability to predict posttransplant outcomes in donor kidneys remains unclear. Methods: We analyzed perfusate cfDNA from 57 hypothermic machine-perfused (HMP) and 56...

Real-time Quality Assessment of Donor Kidneys During Normothermic Machine Perfusion Using Perfusate and Urinary Biomarkers.

Background: Objective, real-time criteria for kidney graft quality during normothermic machine perfusion (NMP) are lacking, contributing to subjective acceptance decisions and organ discard. We evaluated real-time perfusate/urinary biomarkers and perfusion parameters during NMP a...