Erasmus MC Cancer Institute

Applying 177Lu-Dotatate for Hereditary Neuroendocrine Tumours: The Role in MEN1

Abstract Introduction Multiple endocrine neoplasia type 1 (MEN1) is the most common genetic syndrome causing neuroendocrine tumours (NET) with metastatic duodenopancreatic NET (dpNET) forming the predominant cause of MEN1-related mortality. Peptide receptor radionuclide therapy w...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Thymic health and ageing of the T cell system; impact of loss of kidney function

Loss of kidney function is associated with premature immunological aging involving loss of naïve T cells and expansion of pro-inflammatory memory T cells. The changes in the adaptive T cell system contribute to the uremia-related complications of increases susceptibility for infe...

Lobular cancerization in biopsy-diagnosed ductal carcinoma in situ (DCIS) of the breast: a detailed histopathological evaluation and reproducibility study

The role of lobular cancerization in ductal carcinoma in situ (DCIS) of the breast is poorly described to date. A precise definition is lacking. We explored the association between lobular cancerization in biopsy-diagnosed DCIS and different other histopathological features, as w...

The Effect of BMI on the Image Quality of CTA Scans for DIEP Flap Breast Reconstruction

Background: Computed Tomography Angiography (CTA) imaging is currently the gold standard for the preoperative planning of deep inferior epigastric perforator (DIEP) flap breast reconstruction. Limited research has been performed on the effect of body mass index (BMI) on CTA image...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Enabling Evolutionary Therapy in metastatic cancer lacking serum biomarkers

Evolutionary therapy (ET) aims to anticipate and steer tumor evolution by adjusting treatment timing and dosing, often to control rather than eradicate tumor burden. Clinical use requires reliable monitoring of tumor dynamics to inform mathematical models that guide therapy. In c...

Patient-derived organoids as predictor of clinical response in ovarian cancer: a systematic review

Patient-derived organoids (PDOs) have emerged as promising preclinical models for functional drug testing in ovarian cancer, with potential to support personalized treatment selection. However, their predictive value for clinical treatment response remains unclear. This systemati...

Development and Assessment of Poly(ethylene glycol) Diacrylate-Embedded Metalloporphyrin for Phosphorescence Lifetime-Based In Vivo Monitoring of Oxygen Tension

Abstract The timely detection of ischemia is crucial for enhancing outcomes in reconstructive surgery. This study presents the development and in vivo evaluation of a metalloporphyrin-based phosphorescence lifetime oxygen sensor embedded in poly(ethylene glycol) diacrylate (PEGDA...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Single bi-functional flexible sensor device for simultaneous pH and oxygen monitoring during pre-transplant normothermic perfusion

Monitoring of organ health and tissue damage through real-time sensing of chemical parameters such as pH and oxygen concentration could provide helpful information in the field of solid organ transplantation. Several sensors have been developed to detect oxygen concentrations and...

Response to Comment on: “Treatment of therapy-related acute myeloid leukemia and acute myeloid leukemia with myelodysplasiarelated changes: a comparative analysis of higher-dose intensive 7+3 induction chemotherapy versus liposomal cytarabine and daunorubicin”

Not available.

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Transient (Pro)renin receptor silencing disrupts proximal tubule development in human kidney organoids

The (pro)renin receptor [(P)RR] plays a crucial role in murine kidney development, but its function in human kidneys remains poorly understood due to the lack of suitable research models. Human induced pluripotent stem cell (iPSC)-derived kidney organoids recapitulate early kidne...

Facilitating advance care planning in oncology: study protocol for the evaluation of a tailored implementation of an advance care planning tool (the INDEED study)

Abstract Background Advance care planning (ACP) improves patient outcomes, but integration of ACP in daily practice for patients with cancer in hospitals remains suboptimal. Systematic implementation of tools to facilitate ACP could overcome the barriers for ACP. In this study we...

Cost‐Effectiveness of Radiofrequency Ablation for Benign Non‐Functioning Thyroid Nodules: A Systematic Review

ABSTRACT Purpose This systematic review tests the hypothesis that radiofrequency ablation (RFA) for benign non‐functioning thyroid nodules is associated with favourable cost‐effectiveness compared with surgery. Materials and Methods A systematic literature search of multiple data...