Epworth Hospital

Sterility testing in the era of decentralised cell therapy: Challenges, innovations, and future directions

Introduction Chimeric antigen receptor (CAR)-T cell therapies have transformed the treatment of haematological malignancies, yet patients with aggressive, time-sensitive disease remain vulnerable to manufacturing-related treatment delays. Current gold-standard sterility testing u...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Management of De Novo miN1 Prostate Cancer in the PSMA-PET Era.

BACKGROUND: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) is reshaping nodal staging in prostate cancer by detecting regional lymph node metastases with greater accuracy than conventional imaging. This has created a new cohort of patients with N1M0 di...

Economic evaluations of remifentanil versus fentanyl for analgo‐sedation in mechanically ventilated adult ICU patients: a systematic review

Abstract The use of opioid and sedative infusions to relieve pain and anxiety is common among patients receiving invasive mechanical ventilation (IMV) in the intensive care unit (ICU). Although remifentanil‐based sedation is feasible, evidence regarding its economic impact remain...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

Progress and challenges in expanding access to clinical trials in pancreatic cancer

Clinical trials are essential for developing new cancer treatments and improving patient care. However, participation remains low across oncology and is particularly challenging for people with pancreatic cancer, who often experience rapid disease progression, limited treatment o...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Muscle size matters: making paediatric vaccination safe for all - a pilot study

Background/objectives Shoulder Injury Related to Vaccine Administration (SIRVA) is an uncommon but clinically significant iatrogenic complication of vaccination, associated with improper injection depth or site selection. This pilot study aimed to evaluate the suitability of exis...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Bedside assistant models in robotic abdominal and pelvic surgery: a systematic review of operative efficiency, training exposure, and perioperative safety

Robotic surgery depends on effective bedside assistance, yet staffing models vary between physician and non-physician assistants. We systematically reviewed comparative evidence evaluating these models in robotic abdominal and pelvic surgery. A PRISMA compliant systematic review...

Patient‐Reported Outcome Measures Following Pancreatectomy for Pancreatic Cancer: A Scoping Review

BACKGROUND: Patient-reported outcome measures (PROMs) are essential for evaluating quality of life in patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). This scoping review synthesises evidence on PROMs used in this population to guide future research...

Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations

Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relatively uncommon. Early...