Environmental and Occupational Health Sciences Institute

Coreopsis tinctoria and its bioactives in the prevention and management of diabetes and diabetic complications

Abstract Diabetes, one of the major metabolic diseases, has become a major public health concern worldwide leading to chronic lesions in various organs such as kidney and cardiovascular disease, severely impacting quality of life and life expectancy. Current drug treatments for d...

HMGA1 and HMGA2: epigenetic regulators in myeloproliferative neoplasms and novel platelet transcriptomic biomarkers of myelofibrosis

We read with great interest two recent studies by Handa et al. [ 1 ] and Bartalucci et al. [ 2 ] reporting novel chromosomal deletions within the 3’ untranslated region (UTR) of HMGA2 (Δ3’ HMGA2 ) in myeloproliferative neoplasms (MPNs). Both teams identified submicroscopic deleti...

Older Patients and Conservative Kidney Management

Importance In the US, dialysis remains the reflexive treatment option for end-stage kidney disease. Conservative kidney management (CKM), a nondialytic pathway, is infrequently utilized despite the burden dialysis often imposes on patients, caregivers, and health care systems. Ob...

Pediatric Literacy Promotion for Latino Families by Texts and Referrals: A 3-Arm RCT

OBJECTIVE: To test 2 strategies designed to enhance primary care-based literacy promotion (LP): (1) text message reminders (texts), and (2) texts plus referral to community resources. METHODS: We recruited 630 Latino caregiver-infant (aged 6 to 12 months) dyads for an effectivene...

Quantitative in vivo flux analysis reveals tumor and host lipogenic remodeling in KRAS-driven lung cancer

Upregulation of de novo lipogenesis is a hallmark of aggressive cancers, underscoring its potential as a therapeutic target. However, metabolic studies of lipogenesis during tumorigenesis in vivo remain limited relative to molecular investigations. Here, we quantitatively examine...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Modeling climate adaptive habitat connectivity for conservation planning in Colombia

To remain effective under global change, conservation decisions must anticipate shifting climates, species responses to climate change and the dispersal pathways needed to track suitable climate. Yet most assessments of ecological connectivity do not consider how the landscape wi...

Image-aware mixture of experts automates the detection of ovarian follicle rupture in a high-throughput ex vivo ovulation assay

An AI-based dynamic, image-aware Mixture-of-Experts (MoE) framework automates ex vivo ovulation detection and offers a highly accurate, scalable solution for studying the biology of ovulation, drug development, and reproductive toxicity testing.

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design...

Complexity of disconnection dynamics during grain boundary migration

Abstract The Interfacial Line Defect Analysis (ILDA) method is used to fully resolve the time-evolving disconnection network governing migration of the Σ 5(210)[001] symmetric-tilt grain boundary in Al. Rather than proceeding by smooth glide of largely straight disconnections, as...

Chronic disease vulnerability in Ukraine during armed conflict

Abstract Armed conflicts, like the Russian invasion in Ukraine, devastated healthcare systems and amplified chronic disease burdens. This study aimed to unveil novel links between environmental and social factors and chronic illnesses during crises.This study uniquely combined in...

Human‐operant evaluation of synthesized alternative reinforcement and resurgence

Basic research suggests that differential reinforcement with synthesized alternative reinforcement (i.e., delivery of two or more qualitatively different reinforcers contingent on a single alternative response) increases resurgence during disruptions to the contingency. We evalua...

Zidesamtinib (Jideytro®): a new selective, brain-penetrant ROS1 inhibitor approved for the treatment of ROS1-positive non-small cell lung cancer

ROS1-targeted therapies have improved outcomes in ROS1-positive non-small cell lung cancer (NSCLC), but acquired resistance, CNS progression, and off-target toxicities remain important limitations. Zidesamtinib (Jideytro ® , NVL-520) is a next-generation, brain-penetrant, tropomy...

The combination of morphogenic regulators BABY BOOM and GRF ‐ GIF improves maize transformation efficiency and promotes leaf regeneration

Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic laboratories. Here, we present the GGB system,...

Impaired but now diagnosable: Combining analytic frameworks for incorporating symptom weighting in the classification of full‐threshold and subthreshold posttraumatic stress disorder

Abstract Individuals with subthreshold posttraumatic stress disorder (PTSD) often experience significant impairment yet face barriers to care (e.g., insurance denials and exclusion from clinical trials) due to strict Diagnostic and Statistical Manual of Mental Disorders ( DSM )–b...