Ente Ospedaliero Cantonale

Safety and outcomes of real-time ultrasound-guided pericardiocentesis via the left parasternal approach performed by emergency physicians: an 11-year experience

Abstract Aims. Ultrasound-guided pericardiocentesis has largely replaced blind techniques because of its greater safety. No consensus exists regarding the optimal approach. Ultrasound guided pericardiocentesis via in-plane parasternal approach techniques with high-frequency probe...

Urinary tract and genital infections with dapagliflozin and empagliflozin across type 2 diabetes, heart failure, and chronic kidney disease: An indication- and sex-stratified disproportionality analysis of eudravigilance reports

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are widely used in type 2 diabetes mellitus (T2DM), chronic heart failure (CHF), and chronic kidney disease (CKD). Although their cardiovascular and renal benefits are well established, urogenital infections remain a relevant safe...

Nutrition of rotating and daytime shift nurses in medical wards and factors influencing their food choices: A cross-sectional observational study

Background Nutrition is a key component in primary prevention. Shift-working nurses, although trained to follow irregular schedules, often struggle to maintain a healthy diet, which can have potential long-term negative effects on their health. Aim This study aimed to investigate...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...

Transition from laparoscopic to robotic hepatectomy within a minimally invasive liver surgery program: risk-adjusted learning curve assessment by multiple continuous outcomes

Abstract Training in minimally invasive liver surgery (MILS) usually encompasses prior laparoscopic liver resection (LLR) experience before moving to robotic liver resections (RLR). We analyzed the risk-adjusted learning curve of MILS within the transition from LLR to RLR. Consec...

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

No Difference in Short-term Postoperative Complication Rates Between Non-chilled and Chilled Saline Irrigation in Percutaneous Foot and Ankle Surgery

Background: The advent of minimally invasive percutaneous foot and ankle surgery techniques has helped to lower certain complication rates, including wound infection and nonunion. The percutaneous burr is the work horse to perform these procedures. One concern with burr usage is...

Low-Molecular-Weight Heparin Versus Unfractionated Heparin for Venous Thromboembolism Prophylaxis in Adult Traumatic Brain Injury: A Systematic Review and Meta-Analysis

BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) is associated with a high risk of venous thromboembolism (VTE), yet the optimal strategy for thromboprophylaxis remains uncertain. Low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) are commonly used agents...

Clinical Management of Myocardial Infarction

Despite notable advancements in the acute and long-term management, coronary artery disease and myocardial infarction (MI) remain the leading cause of mortality worldwide. Atherothrombosis overlying coronary plaque rupture or erosion is the main pathophysiological mechanism of MI...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...