Enamine (Ukraine)

Structure based discovery of antipsychotic-like TAAR1 agonists

Abstract Schizophrenia is a severe mental illness whose current treatments primarily target dopamine and serotonin receptors. These drugs often cause side effects and vary in effectiveness across patients. The trace amine-associated receptor 1 (TAAR1), which modulates monoamine s...

Pushing the boundaries of virtual screening scale of combinatorial spaces with the V-SYNTHES approach

Computational screening of giga-scale chemical spaces opens a cost-effective path to high-quality hit identification, providing entry points for drug discovery. As these on-demand spaces grow and successful applications multiply, rigorous blind benchmarks like CACHE Challenges pr...