EN-FIST Centre of Excellence (Slovenia)

Local androgen and 11-oxyandrogen metabolism and signaling emerges as a novel prognostic and therapeutic axis in high-grade serous ovarian cancer

Abstract Background High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy, exhibiting marked heterogeneity that complicates treatment. The implications of intratumoral androgen metabolism and signalling, particularly involving 11-oxygenated androge...