Emory University Hospital

Review Article of Platelet-Rich Plasma and Facet-Mediated Mechanical Low Back Pain

Introduction and Aim: Facet-mediated mechanical low back pain is a common contributor to chronic disability worldwide. While platelet-rich plasma (PRP) has demonstrated efficacy in discogenic low back pain, its role in facet joint-mediated pain remains less clearly defined. This...

Myocardial Strain Evaluation from Cardiovascular MRI and CT: Physiological Principles and Clinical Perspectives

Abstract Global markers of myocardial function are limited in the information they provide, warranting the need for local markers that are sensitive and specific to myocardial physiology. Myocardial deformation, quantified by strain, is a robust marker of myocardial function that...

Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis

BACKGROUND: Drug-coated balloons (DCB) are superior to conventional balloon angioplasty in coronary in-stent restenosis. The influence of chronic kidney disease (CKD) on outcomes after DCB for in-stent restenosis is not well described. METHODS: A post hoc analysis of the AGENT ID...

Association of peri-reperfusion oxygen exposure and early allograft dysfunction after deceased donor orthotopic liver transplantation: a retrospective cohort study

Hepatic insufficiency within a week of orthotopic liver transplantation (OLT), termed early allograft dysfunction (EAD), occurs in 20–25% of deceased donor OLT recipients and carries substantial morbidity and mortality. Ischemia reperfusion injury, in which reperfusion after isch...

Thrombotic Thrombocytopenic Purpura Causing Multiple Large Vessel Occlusions: A Case Report

Background Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder characterized by a severe deficiency or absence of the disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 enzyme (ADAMTS13), which is a protease essential for cleaving von Wi...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...