Emory University Hospital

Thrombotic Thrombocytopenic Purpura Causing Multiple Large Vessel Occlusions: A Case Report

Background Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder characterized by a severe deficiency or absence of the disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 enzyme (ADAMTS13), which is a protease essential for cleaving von Wi...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...