Emory Healthcare

Review Article of Platelet-Rich Plasma and Facet-Mediated Mechanical Low Back Pain

Introduction and Aim: Facet-mediated mechanical low back pain is a common contributor to chronic disability worldwide. While platelet-rich plasma (PRP) has demonstrated efficacy in discogenic low back pain, its role in facet joint-mediated pain remains less clearly defined. This...

From policy to practice: overcoming barriers to harm reduction vending machine deployment

Drug overdose deaths remain a leading cause of mortality in the U.S., largely driven by a drug supply frequently contaminated with fentanyl. Harm reduction vending machines (HRVMs) provide low-barrier access to naloxone and fentanyl testing strips (FTS). However, legacy state law...

Strategies To Sustain the U.S. Pediatric Anesthesiology Workforce

Pediatric anesthesiology is a deeply rewarding specialty, and the job market remains favorable for the trainees who choose it. However, the U.S. pediatric anesthesiology workforce is facing a convergence of challenges, including declining fellowship recruitment, increasing nonope...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...

Combinatorial action of regulatory systems generates colistin heteroresistance

ABSTRACT Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresistance is common among Enterobacter cloacae clinical isolates, threatens its utility as a last-line t...

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding...