Eisai (United States)

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease

Importance In trials targeting preclinical Alzheimer disease (AD), defined as amyloid pathology without cognitive symptoms, racial and ethnic differences in plasma phosphorylated tau 217 percentage (%p-tau217) may influence screening eligibility. Objective To characterize racial...

From Biomarker Anchors to Disease-State Transitions: A Biologically Anchored Probabilistic Principal Component Analysis Framework for Alzheimer’s Disease Progression Modeling

To develop and validate a biomarker-anchored probabilistic principal component analysis (PPCA) framework for identifying biologically interpretable latent dimensions of Alzheimer’s disease (AD) and evaluating their utility for disease progression modeling. Data from 1058 particip...

Back to economic fundamentals: a welfare-based accounting framework for societal value in health technology assessment

Practical adoption of “novel” value elements in value assessment remains uneven, in part because components are often defined inconsistently and may overlap. We develop a welfare-grounded accounting framework to organize societal value components and clarify when proposed element...