Eijkman Institute for Molecular Biology

Cryo-EM structures of the SurA–BAM complex reveal conformational changes in outer membrane protein assembly

The outer membrane (OM) of Gram-negative bacteria acts as a permeability barrier against toxic compounds. Its integrity is maintained by various outer membrane proteins (OMPs), which are inserted into the OM by the β-barrel assembly machinery (BAM) complex. The periplasmic chaper...

The molecular spectrum of alpha- and beta-thalassemia pathogenic variants in Indonesia: implications for national screening and prevention

Abstract Background Thalassemia is classified globally as a rare disease; however, it represents a major public health burden in many low‑ and middle‑income countries due to its high prevalence and limited access to care. In Indonesia, one of the world’s most genetically diverse...

Intraspecies genetic diversity and host-associated distribution of Endolimax nana in Sumba Island, Indonesia

Endolimax nana is a common intestinal archamoebid within Evosea (Amoebozoa), alongside genera such as Entamoeba , Iodamoeba , and Mastigamoeba . Despite its frequent colonization of humans, it has received limited attention as a presumed non-pathogenic commensal, and its genetic...