Eighth Affiliated Hospital of Sun Yat-sen University

BIRC3 facilitates osteogenic differentiation of bone marrow mesenchymal stem cells via NGFR/β-catenin signalling axis

Aims: Osteoporosis primarily results from age-related declines in bone marrow mesenchymal stem cell (BMSC) differentiation into osteoblasts; however, the regulatory mechanisms remain unclear. Methods: Integrated analysis of Gene Expression Omnibus (GEO) and RNA sequencing (RNA-se...

The mediating role of social determinants of health in the association between adverse childhood experiences and later-life cardiovascular disease

To investigate the longitudinal association between adverse childhood experiences (ACEs) and incident cardiovascular disease (CVD) in later life, and to examine whether the integrated construct of adult social determinants of health (SDH) mediates this association among middle-ag...

Perirenal fat thickness was associated with reduced estimated glomerular filtration rate in the hospital-based population: a mediation analysis

It is unclear how perirenal fat thickness (PrFT) and impaired renal function are related, particularly in patients with metabolic risk factors. A hospital-based cohort of individuals was examined to determine whether perirenal fat thickness, as measured by magnetic resonance imag...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

Synthetic nanoplatforms for multiscale imaging in living organisms

Abstract The rapid advancements in nanotechnology have promoted transformative breakthroughs in biomedical imaging, with global research in this field exhibiting exponential growth and numerous cutting-edge achievements widely reported. This review systematically summarizes the e...

AR/PARP Dual‐Targeting Bioactive Photosensitizer for Photo‐Immunotherapy of Prostate Cancer

Prostate cancer poses a severe threat to men's health worldwide, and conventional therapeutic modalities are associated with various limitations. Photodynamic therapy (PDT) offers distinctive advantages such as minimal invasiveness, mild side effects and repeatable treatment. How...

48-hour BPRI trajectories and 28-day mortality in vasoactive-supported hypertensive heart disease with heart failure

Hypertensive heart disease (HHD) complicated by heart failure is associated with high mortality in intensive care units. The Blood Pressure Response Index (BPRI), the ratio of mean arterial pressure to vasoactive-inotropic score, integrates hemodynamic targets and treatment inten...

Mutations in EnvZ, KPC, and OmpK36 contribute to the evolution from ceftazidime-avibactam heteroresistance to stable resistance in carbapenem-resistant Klebsiella pneumoniae

Antibiotic heteroresistance, an unstable phenotype wherein a minority-resistant subpopulation coexists with a majority-susceptible population, can evolve to stable resistance following in vivo antibiotic exposure, thereby substantially increasing the risk of treatment failure. Ho...

Single-Cell RNA Sequencing Combined with MEBOCOST Reveals Alveolar Macrophage-Mediated Immunometabolic Communication Mechanisms in Sepsis-Induced Acute Lung Injury

Background: Sepsis-induced acute lung injury (SI-ALI) leads to high mortality in critically ill patients, and no specific targeted treatments are available. Current studies mainly characterize intercellular crosstalk via protein–ligand–receptor frameworks, while metabolite-derive...

Measured resting energy expenditure via indirect calorimetry of critically ill patients: A comparison with predictive equations.

BACKGROUND AND OBJECTIVES: Assessing the resting energy expenditure (REE) of critically ill patients is essential for individual nutritional programs. We hypothesized that different evaluated ways for REE can be compared, and REE may be associated with disease severity and clinic...