Egyptian Atomic Energy Authority

Pharmacokinetic-Modifying Linker Design Modulates Performance of Multivalent PSMA/GRPR-Cell-Targeting 177Lu Radiopharmaceuticals

Background/Objectives: A series of PSMA/GRPR-targeting compounds were selected based on modifications to their respective pharmacokinetic-modifying linking groups and the structure of the PSMA-binding moiety, to examine how these alterations impact binding affinity and specificit...

Optical, thermal, and thermomechanical tailoring of PVA/CMC/CNT nanocomposites via CdS incorporation

In this study, polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) nanocomposite films reinforced with carbon nanotubes (CNTs) and 1, 2, and 3 wt% CdS nanoparticles were successfully fabricated via a facile solution-casting method. XRD and FTIR analyses confirmed the preservation...

Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins

The gradual loss of cognitive function, manifested by impaired learning and spatial memory, is a hallmark of brain senescence during aging. However, effective natural interventions targeting multiple mechanisms involved in aging-related neurodegeneration remain limited. This stud...

Molecular and immunological effects of ivermectin and/or low dose gamma-radiation on Schistosoma Mansoni infected mice

Abstract Background Schistosomiasis remains a public health concern with limited therapeutic options and rising resistance to praziquantel. Aim To evaluate the efficacy of ivermectin, alone and combined with low dose gamma-radiation, against Schistosoma mansoni infection. Methods...

Gamma irradiation effects on optical, luminescent, and electrical properties of CeO2, Ho2O3, and Sm2O3 doped borophosphate glasses

Abstract A series of undoped and rare-earth oxide-doped borophosphate glasses (CeO 2 , Ho 2 O 3 , Sm 2 O 3 ) was successfully synthesized via melt-quenching and annealing techniques, with x-ray diffraction confirming their amorphous nature through characteristic broad halos devoi...

“Radiation-Synthesized Gallotannin Hydrogel Attenuates Trisenox-Induced Nephrotoxicity in Rats: miR-223/TXNIP Axis Modulation of Oxidative Stress and Inflammation”

Arsenic trioxide (ATO) is a potent therapeutic agent against acute promyelocytic leukemia; nevertheless, its clinical utility is severely restricted by dose-limiting nephrotoxicity. This study investigated the protective potential of a radiation-synthesized gallotannin hydrogel (...

Selective separation of Ag(I)/Pd(II) using mesoporous Mn 3 O 4 for 111 Ag production

Abstract Mesoporous Mn 3 O 4 was developed as an efficient single-step sorbent for the selective separation of Ag + from Pd 2+ , enabling a practical approach for the production of carrier-free 111 Ag. The material was synthesized via a CTAB-assisted co-precipitation method and c...

Visual image perception preservation through a compression-encryption framework

Abstract Tracking of 1D and 2D characteristics of a monitored environment can be tracked using Wireless Sensor Networks (WSN). Millions of photos that have confidential shots are sent every day across the network and they are required to be transferred safely; accordingly, securi...

Hybrid chemical and physical activation techniques for engineering hierarchical pore structures in activated carbon for enhanced adsorption performance

<title>Abstract</title> This study explores the synergistic impact of hybrid chemical activation (CA) and physical activation (PA) on creating hierarchical pore structures in activated carbons (ACs) derived from various biomass precursors, aiming to improve adsorption performance...

Combined Omeprazole and Glycyrrhiza glabra L. Extract Attenuate Ethanol-Induced Gastric Ulceration Through Modulation of TLR4/NF-κB/NLRP3 Signaling and Upregulation of PI3K/AKT/mTOR Gene Expression

Ethanol (EtOH)-induced gastric ulcer (GU) is a common model used to investigate mechanisms of mucosal injury and repair. Omeprazole (OMP) is a conventional anti-ulcer drug that effectively suppresses gastric acid secretion, but its efficacy may be enhanced by combining it with bi...