Eginition Hospital

Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits

Dementia with Lewy bodies (DLB) is increasingly conceptualised not merely as a disorder of neuronal death but as a primary synaptopathy in which the functional collapse of synaptic transmission and plasticity precedes, and predicts, neurodegeneration and clinical decline. Two gen...

Interleukins and Cardiovascular Disease

Interleukins are important inflammatory cytokines involved in cardiovascular (CV) disease (CVD) pathogenesis, particularly in atherosclerosis, by regulating inflammation, endothelial dysfunction, plaque formation, thrombosis, immune responses, and hematopoiesis. High levels of in...