Edward Hines, Jr. VA Hospital

Identifying incident medication‐related osteonecrosis of the jaw and antiresorptive drug holidays using natural language processing on clinical notes in men and women prescribed bisphosphonates or denosumab for fracture prevention

OBJECTIVE: Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive therapy for osteoporosis, with risk potentially influenced by "drug holidays" around dentoalveolar procedures. MRONJ risk is higher in rheumatic diseases. Epidemiologic studies...

Radiation-Induced Proctitis and Hemorrhagic Cystitis

Radiation therapy is a cornerstone in the management of pelvic and thoracic malignancies, but injury to surrounding normal tissue remains a clinically significant source of late morbidity despite advances in treatment delivery. Radiation-induced proctitis and hemorrhagic cystitis...

Examining Trust Among Veterans from Camp Lejeune Exposed to Environmental Toxicants: A Qualitative Study

Abstract Background Serving Veterans with military environmental exposures is a top priority of the Veterans Health Administration (VHA). This priority is critical for over 1 million Veterans and civilians who were exposed to contaminated drinking water at United States Marine Co...

Natural Language Processing to Improve Vertebral Fracture Identification in Older Adults Receiving Osteoporosis Therapy

INTRODUCTION: Vertebral fracture identification using administrative codes is challenging because diagnoses often occur outside hospital and orthopedic care settings. Outpatient diagnoses improve capture but increase misclassification. Accurate methods are important for populatio...

Diagnosis and management of acute hyperkalaemia

Abstract Hyperkalaemia is a common and potentially life threatening electrolyte abnormality because of its association with malignant cardiac arrhythmias and sudden cardiac arrest. This condition is frequently encountered across acute and chronic care settings and disproportionat...

Artificial Intelligence in Thyroid Nodules and Cancer: Clinical Validation and Real-World Performance

Abstract Thyroid nodules are detected in a large proportion of adults undergoing high-resolution ultrasonography, yet only a minority harbor clinically significant cancer. The clinical problem is therefore not only cancer detection but calibrated risk stratification: avoiding del...