Education Training And Research

First-trimester aggregate index of systemic inflammation and adverse pregnancy outcomes in hospitalized women with threatened miscarriage: a single-center retrospective cohort study

Abstract Background Complete blood count-derived inflammatory indices have been associated with miscarriage, but the incremental value of the aggregate index of systemic inflammation (AISI) beyond established indices such as the systemic immune-inflammation index (SII) remains un...

Temporal distribution of recorded intensive care unit deaths across the 24-hour cycle: a 15-year retrospective hospital-based study

Whether recorded deaths in intensive care units (ICUs) follow a uniform temporal distribution throughout the 24-hour cycle remains uncertain. Previous studies have primarily compared broad day–night periods, potentially overlooking finer temporal patterns. We investigated the tem...

Atherogenic and inflammatory biomarkers in NSTEMI: a comparative analysis of predictive value for obstructive coronary disease

Background The atherogenic index of plasma (AIP) and inflammatory indices may reflect the burden of atherosclerosis. This study evaluated their predictive value for obstructive coronary artery disease (CAD) in patients with non-ST-elevation myocardial infarction (NSTEMI).Methods...

Diagnosis, management, and prevention of Crimean-Congo haemorrhagic fever: a Delphi-based consensus study in Türkiye

Background Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed viral haemorrhagic fever with expanding geographic range. As new regions encounter the disease, clinicians must make high-stakes decisions despite limited standardised management frameworks. Methods In thi...

Mesenteric Hyaline Vascular Castleman Disease Presenting as Acute Mechanical Intestinal Obstruction

The Annali Italiani di Chirurgia (ISSN/eISSN: 0003-469X/2239-253X) is the oldest surgical journal in Italy. It covers all aspects of surgery and its allied disciplines, including elective, emergency and experimental surgery, as well as problems involving technology, teaching, org...

NBN rs1805794 Polymorphism Increases the Predictive Performance of Machine Learning Models for Multiple Chronic Toxicities in Head and Neck Cancer Survivors Treated with Definitive Radiotherapy ± Chemotherapy

Objective: While advancements in radiotherapy and systemic agents have significantly improved survival rates in head and neck squamous cell carcinoma (HNSCC), managing long-term, treatment-induced toxicities remains a critical clinical challenge. This study aimed to develop a per...

Computed tomography–based assessment of gluteal muscle asymmetry one year after total hip arthroplasty and its relationship with postoperative function

This study aimed to compare gluteal muscle quantity and quality between the operated and contralateral sides one year after unilateral total hip arthroplasty (THA). Muscle thickness, cross-sectional area (CSA), and muscle density of the gluteus maximus (Gmax), gluteus medius (Gme...

Surgical treatment of anal fistula: classic elastic seton application and LIFT method

Anal fistulas remain a challenging problem in colorectal surgery, and the optimal sphincter-preserving technique is still debated. We compared the LIFT procedure and elastic seton application in terms of treatment outcomes, postoperative pain, anal continence, and quality of life...

Mentalization and Emotion Regulation Difficulties in Adolescent Girls With Social Anxiety Disorder

INTRODUCTION: Social anxiety disorder (SAD) is a prevalent disorder that often begins during adolescence, leading to considerable challenges in social functioning and overall mental health. Previous studies have demonstrated that mentalization deficits and emotion regulation diff...

Asparagine synthetase deficiency: clinical features and experience with asparagine supplementation

Abstract Objectives Asparagine synthetase deficiency is a rare autosomal recessive neurometabolic disorder characterized by congenital and progressive microcephaly, severe developmental delay, epilepsy, and progressive cerebral atrophy. Therapeutic experience with L-asparagine su...

The Role of Immature Granulocyte Count and Percentage as Novel Indicators of Systemic Inflammation in Plaque Psoriasis

Background/Objective: Psoriasis is a chronic immune-mediated inflammatory disease with systemic involvement. Immature granulocytes (IGs) are potential inflammatory markers, but their role in psoriasis is unclear. We evaluated immature granulocyte count (IG#) and percentage (IG%)...

Reduced Vagal Compound Action Potential Amplitude Is Associated with Glomerular Injury in an Experimental Rabbit Model of Severe Subarachnoid Hemorrhage

Background: Subarachnoid hemorrhage (SAH) induces a sympathetic surge and systemic inflammation that may impair renal perfusion and glomerular integrity. Although the vagus nerve is central to autonomic and anti-inflammatory regulation, its relationship to renal structural injury...

Separation Anxiety in Emerging Adults: The Role of Attachment Styles and Personality Traits

Objective To examine childhood and adult separation anxiety symptoms and their associations with attachment styles, personality traits, and sociodemographic factors among university students.Methods This cross-sectional study included 200 first-year university students. Attachmen...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Integrated serum and synovial biomarker profiling reveals inflammatory and cartilage remodeling signatures in age-restricted knee osteoarthritis

Knee osteoarthritis (OA) is a complex disease characterized by inflammation, cartilage degeneration, and tissue remodeling. Although many biomarkers have been investigated, the combined biological significance of systemic and local biomarkers is not fully understood. This study a...

The general mental health conditions and related factors of the occupational health physicians working in Ankara Province

This study aimed to evaluate the personal and occupational factors associated with the general mental health status of occupational physicians. In this cross-sectional survey, data were collected through a self-administered online survey consisting of the General Health Questionn...

Incidence and risk factors of incisional hernia after CRS and HIPEC for colorectal-appendiceal peritoneal malignancies: a retrospective cohort study

Abstract Background Incisional hernia is a common late complication after extensive abdominal surgery and may significantly impair quality of life. The incidence and risk factors of incisional hernia in patients undergoing cytoreductive surgery (CRS) combined with hyperthermic in...