Edmond and Lily Safra Children's Hospital

Two-Year Clinical Outcomes of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression

OBJECTIVES: To assess 24-month clinical outcomes of vagus nerve stimulation (VNS) in individuals with higher-grade treatment-resistant depression (HG-TRD) treated within a national open-label program, focusing on depressive severity, suicidality, safety, tolerability, and rates o...

Three-Dimensional Transthoracic Echocardiography as a Tool for Patient Selection for Percutaneous Atrial Septal Defect Closure

Abstract Planning for percutaneous closure of large atrial septal defects presents a challenge for pediatric cardiologists. Transcatheter repair is preferred to open heart surgery however in borderline cases, it may be difficult to assess whether the tissue rims around the atrial...

Understanding Caregivers’ Experiences of Rett Syndrome: A Multinational Study of Symptoms and Meaningful Outcomes of Potential Treatments

Caregivers have first-hand experience of facing the daily challenges of Rett syndrome (RTT). The aim of this study was to understand caregivers’ experiences of RTT, including challenging symptoms that caregivers hope novel therapies will address. This non-interventional, qualitat...

Standardizing Fertility Preservation Counseling for Pediatric Hematology–Oncology and Transplant and Cellular Therapy Patients: A Quality Improvement Initiative

BACKGROUND: Infertility following gonadotoxic chemotherapy is among the most distressing late effects experienced by childhood cancer survivors, highlighting the importance of fertility preservation (FP) counseling at the time of diagnosis. We aimed to improve the frequency and c...