École Nationale Vétérinaire de Toulouse

Integrated adipose tissue transcriptomic and miRNA remodeling identifies molecular pathways associated with residual cardiovascular risk after weight loss

Abstract Background Weight loss improves cardiometabolic health, yet substantial inter-individual variability remains in residual cardiovascular risk. Here, we investigated whether post-weight loss adipose tissue (AT) molecular remodeling is associated with this variability. Meth...

Vocal encoding of heritable sociability prevails over emotions in sheep bleats

Vocalizations of animals are good indicators of their emotions. Temperament is known to influence the regulation and expression of emotions. However, how animal temperament affects their vocalizations and particularly their vocal expressions of emotions remains largely unexplored...

Perinatal exposure to nano-polystyrene: deleterious imprinting on inflammatory bowel diseases

The extent of production and use of plastics leads to release of nanoplastics (NPL) into the environment, where they undergo weathering that could alter their toxicological properties. NPL enter the human food chain via contaminated food, and food packaging, and within the body t...

NucGen3D: A synthetic framework for large-scale 3D nuclear segmentation with open-source training data and models

A bstract Robust nuclear segmentation in 3D microscopy images is a critical yet unresolved challenge in quantitative cell biology, hindered by the scarcity and variability of annotated volumetric datasets. Because such data are difficult to obtain, most state-of-the-art approache...

Leveraging human-trained neural networks for cross-species chromatin regulation annotations

Abstract Analogous to the Encyclopedia of DNA Elements (ENCODE) project, the Functional Annotation of ANimal Genomes (FAANG) consortium has produced chromatin annotations for domesticated animals, albeit in smaller amounts. Although acquiring experimental data is more accessible...

Selective culling and the potential persistence of lumpy skin disease in cattle herds: insights from a mechanistic transmission model

Abstract The first epidemic of lumpy skin disease (LSD) in France was detected in June 2025, with a total of 117 outbreaks recorded by the end of the year. This fast-spreading vector-borne disease of cattle prompted the implementation of strict control measures, including total d...

The calf holobiont under challenge: longitudinal microbiota–pathogen dynamics and respiratory health

The bovine respiratory disease complex (BRDC) is a major health and welfare challenge driven by multifactorial interactions among pathogens, the host, the microbiota, and environmental pressures, reflecting the holobiont nature of the calf. Many implicated bacterial pathogens are...

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of...

Investigating Mycoplasma wenyonii and Candidatus Mycoplasma haematobovis coinfection patterns in cattle from southwestern France reveals strain-specific traits

Abstract Hemotropic mycoplasmas (hemoplasmas) infecting cattle were first detected in France in 2019 during a clinical outbreak, but their prevalence both at the species and strain levels remains unknown. This study therefore aimed to determine the prevalence of hemoplasmas and t...