Ecogenomics (Japan)

External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts

Objectives To determine whether bacterial- and viral-associated whole-blood host-response modules discovered in GSE211567 retain their prespecified directions when applied unchanged to two external cohorts, including a second cross-platform cohort, and to quantify their robustnes...

Restrictome-EVOLVE: population-resolved haplotype architecture of human antiviral restriction-factor loci

Human antiviral restriction factors act across multiple stages of viral replication, but whether their population-resolved haplotype architecture differs systematically from comparable genomic regions is unclear. We tested this using phased public human genomic data from 660 indi...

Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea

Abstract Ammonia-oxidizing archaea (AOA) are widespread in nature and contribute to global carbon and nitrogen cycling. Although their energy production is an aerobic process, AOA occur in environments of low oxygen and in fully anoxic zones. Recently, oxygen production under ano...