Eckert & Ziegler (United States)

A Nontoxin Aminopyrimidine Probe for Near State-Independent NaV1.7 Inhibition

Abstract The voltage-gated sodium channel NaV1.7 is among the most compelling genetically validated pain targets; however, advanced small-molecule inhibitors, including voltage-sensing domain IV (VSD4)-directed series, have not yet achieved robust clinical efficacy, potentially r...

Clinical Characteristics and Outcomes of Melanoma Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elderly Population: A Cohort Analysis Over 10 Years

Introduction: Outcomes among the Hispanic population are rarely explored in adolescents and young adults (AYAs). We aimed to compare sociodemographic, clinical, and survival outcomes of Latin American AYAs (≤39 years) with middle-aged (40–59 years) and older (≥60 years) patients...