Eastern Hepatobiliary Surgery Hospital

CD147+ Cancer‐Associated Fibroblasts Promote PD‐L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL‐6 Signaling

BACKGROUND: Targeting CD147 on hepatocellular carcinoma (HCC) cells has demonstrated therapeutic efficacy. Cancer-associated fibroblasts (CAFs) have been identified as critical components of the tumor microenvironment. The role of CD147 in CAFs is still unclear, and this study ai...

Development and application of simple self-locking surgical tubing tourniquet for laparoscopic Pringle maneuver

Pringle maneuver is a critical technique for controlling hepatic inflow and minimizing blood loss during laparoscopic liver resection. However, traditional methods of performing this maneuver can be cumbersome in laparoscopic settings. This study introduces a simple self-locking...

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-based neoadjuvant therapy. Bulk transcriptomic analyses cannot resolve epithelial-state heterogeneit...

Hospice care volunteers’ experiences of reflecting on life meaning: a descriptive phenomenological study

Hospice care volunteers are an important part of spiritual care in hospice settings. Through active listening and dialogue, they can help terminally ill patients rediscover and affirm the value of life and the meaning of existence that may have been obscured during illness. Howev...

Hepatitis B virus pregenomic RNA is associated with malignant phenotypes and postoperative survival in HBV-related intrahepatic cholangiocarcinoma

Abstract Background Chronic hepatitis B virus (HBV) infection contributes to infection-associated liver carcinogenesis. However, the biological and clinical relevance of HBV pregenomic RNA (pgRNA), a marker of residual viral transcriptional activity, in HBV-related intrahepatic c...

Optimal timing of endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: a multicenter retrospective analysis

To compare the clinical outcomes of ERCP combined with laparoscopic LC using both one-step and two-step approaches for the treatment of cholecystocholedocholithiasis, and to investigate the optimal timing for performing LC within two weeks after ERCP. The clinical data of 520 pat...

Endoscopic Intervention and Surgical Treatment of Benign Biliary‐Enteric Anastomotic Stricture: Real‐World Clinical Impact

OBJECTIVES: Although endoscopic interventions and surgery are both used for treating bening biliary-enteric anastomotic stricture (BEAS), their comparative efficacy, safety, and economic impact have not been established. We conducted this study to address that gap. METHODS: Patie...

Metal–OrganicFrameworks (MOFs) for the Deliveryof Small-Molecule Therapeutics

Abstract As cutting-edge porous materials, the properties of metal–organic frameworks (MOFs) are governed by their metal nodes and organic linkers, as well as the assembly mode of these subunits. This allows the loading capacity of MOFs for small-molecule drugs to be readily tail...

The VASN-YAP-MYL9 axis drives M2-like macrophage polarization and immune evasion in colorectal cancer

Tumor-associated macrophages (TAMs) polarized toward an M2-like phenotype are critical drivers of immunosuppression in colorectal cancer (CRC). While Vasorin (VASN) is implicated in poor prognosis, its specific role in orchestrating the tumor immune microenvironment remains elusi...