Eastern Health

Chronic pain treatment experiences and barriers among opioid agonist treatment participants who inject drugs: A qualitative study

Abstract Background and aim Co‐occurring chronic pain affects nearly half of people receiving opioid use disorder (OUD) treatment. Although this pain is often severe, it is usually inadequately managed. Stigma and clinical complexity associated with OUD are thought to further res...

A decade of cannabis‐related hospital admissions in Victoria, Australia: A retrospective observational study

BACKGROUND AND AIMS: Over the past decade, there has been increased lifetime use of illicit and medical cannabis, underscoring the need to examine public health impacts. This includes reports of increased cannabis-related psychosis. In this context, this study aimed to determine...

A call for action with the burden of cirrhosis in Australia

Unlike most other chronic diseases and cancers in Australia, outcomes for cirrhosis and hepatocellular cancer are not improving. Public hospitals are overwhelmed by decompensated cirrhosis and struggling to provide best practice care for the large population of patients with less...

Uptake of postpartum diabetes screening after gestational diabetes: a five-year institution-based retrospective study in Ethiopia

Women with a history of gestational diabetes are at a high risk of progression to type 2 diabetes, which makes postpartum diabetes screening a crucial preventive measure. Evidence on postpartum diabetes screening uptake is limited in Ethiopia. We assessed postpartum screening pra...

Insulin‐Like Growth Factor Axis and Survival in Metastatic Hormone‐Sensitive Prostate Cancer: Post‐Hoc Analysis From the ENZAMET Phase 3 Trial

ABSTRACT Background A higher ratio of IGF‐1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone‐sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of a...

Strategies for integrating artificial intelligence and cognitive assessment to predict disability progression in relapsing-remitting multiple sclerosis: A model development study

Serial cognitive assessment in multiple sclerosis can help identify patients at higher risk of disability progression, but high dimensionality of reaction-time data makes analysis challenging. We developed a method to convert longitudinal reaction-time data into images and applie...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Deprescribing interventions in older adults with cancer: A systematic review and meta-analysis

Introduction Polypharmacy and use of potentially inappropriate medications (PIMs) in older adults with cancer are associated with increased morbidity and mortality. Deprescribing is a structured, patient-centred intervention for reducing PIMs; however, the outcomes of deprescribi...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

A qualitative study of cancer survivors’ exercise behaviour 4 months after a telerehabilitation program

Abstract Purpose Although telerehabilitation can improve access to exercise programs for cancer survivors, it is not known if these programs lead to ongoing change in exercise habits. This study explored participant experiences of exercise 4 months after finishing specialized can...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer’s disease: sequence and timing

Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery. Characterising the temporal profile of plasma biomarker levels in presymptomatic individuals may enhance understanding of disease pathogenesis, inform futur...

The experiences of detection of minor drug offences for people with mental health concerns: A qualitative study

There is a strong and complex relationship between drug use disorders and mental health and people arrested for minor drug offences are no exception. The aim of this study was to explore the experiences of detection for minor drug offences among people reporting mental health pro...

Aorto‐Ostial Lesion Percutaneous Coronary Intervention: Clinical Characteristics, Predictors and Clinical Outcomes

ABSTRACT Background Aorto‐ostial coronary lesions represent a high‐risk subset of coronary disease because of fibrocalcific disease, elastic recoil, and difficulty achieving precise stent positioning. Percutaneous coronary intervention (PCI) of these lesions may therefore be asso...

Characterising the Beyond 50 Cohort: Preliminary Exploration of Physical and Psychosocial Health Factors and Substance Use Among a Cohort of Community Dwelling Adults Aged 50–70 Years

ABSTRACT Introduction Older adults exhibit unique risks associated with poor mental health and substance use. The Beyond 50 study is a longitudinal cohort investigating the determinants of healthy ageing, including relationships between physical and psychosocial health and substa...

“Just a number” – larger-bodied women’s experiences of weight-centric and weight-inclusive maternity care: a national online photovoice study

Abstract Background Weight stigma is a pervasive issue in healthcare, including maternity care, characterised by bias, discrimination, and exclusion. Experiencing weight stigma can negatively impact health outcomes, self-esteem, and engagement with care. While existing literature...