E-Da Hospital

Association of perioperative etomidate exposure and mortality after hip fracture surgery: a matched cohort study

Etomidate is often used for anesthetic induction in hemodynamically unstable patients because of its cardiovascular stability, but its transient adrenal suppression raises concern about possible adverse postoperative outcomes. We performed a cohort study using the TriNetX Researc...

Targeting the Gut to Modify Parkinson's Disease: From Mechanisms to Potential Therapeutics

Parkinson's disease (PD) is the second most common neurodegenerative disorder and its prevalence continues to rise with population aging. Its cardinal motor features arise from the loss of dopaminergic neurons in the substantia nigra, accompanied by intraneuronal α-synuclein aggr...

Diagnosis of tuberculous lymphadenopathy: the role of droplet digital PCR

Background: Tuberculous lymphadenopathy (TB-LAP) is the most common form of extrapulmonary TB and remains diagnostically challenging due to its paucibacillary nature. We evaluated the diagnostic performance of droplet digital PCR (ddPCR) for detecting Mycobacterium tuberculosis (...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Impact of Baseline Synchronous Adenoma Burden on the Risk of Metachronous Advanced Neoplasia

Background and study aim: Individuals classified as “high-risk” at initial colonoscopy face an elevated risk of metachronous advanced colorectal neoplasms (meta-ACRN), but risk heterogeneity within this group remains unclear. We aimed to stratify meta-ACRN risk among high-risk in...

Effects of Ageism, Depression, Physical Resilience, and Frailty on Quality of Life Among Older Women

In Taiwan, as a super-aging society, older women face unique challenges that affect their health and quality of life (QoL). The present 1-year longitudinal study was conducted to examine changes in physical and psychosocial health and the relationship between these factors and Qo...

Prevention of new-onset chronic kidney disease with renin–angiotensin system blockers in type 2 diabetes with preserved kidney function

Renin–angiotensin system (RAS) blockers, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are known to slow chronic kidney disease (CKD) progression in patients with established renal impairment. However, whether RAS blockade ca...