Dunedin Public Hospital

Rewriting the cancer epigenome: CRISPR technologies for DNA methylation editing

Abstract Aberrant DNA methylation is a fundamental hallmark of cancer, characterized by widespread global hypomethylation, focal hypermethylation of key regulatory regions, and extensive disruption of gene regulatory and epigenomic networks. Despite comprehensive methylome profil...

From Deposits to Overdrafts: Dynamic Portfolio Adjustment and Financial Fragility in a Sraffian Supermultiplier Stock‐Flow Consistent Model

ABSTRACT This paper develops a Sraffian Supermultiplier Stock–Flow Consistent (SSM‐SFC) model in which the growth of government expenditure anchors long‐run demand‐led growth. It replaces Tobin‐style desired stocks with dynamic portfolio adjustment: households rebalance deposits,...

Uptake of at-home self-collected dried blood spots for HIV, hepatitis C and syphilis screening among Māori gay, bisexual and other men who have sex with men in Aotearoa New Zealand: an observational epidemiological study

Background HIV testing is an integral component of prevention, reducing undiagnosed infection and promoting early treatment. Indigenous gay, bisexual and other men who have sex with men (GBM) are at increased risk of HIV and sexually transmitted infections (STIs), but may experie...