Duke University Health System

Surgical and Radiographic Outcomes in Cervical Deformity Patients with High T1 Slope and High C2 Slope (HTHC) Versus Low T1 Slope and High C2 Slope (LTHC)

Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...

Inpatient Pediatric-to-Adult Transition of Care Consultation Delivery: A Mixed-Methods Study

OBJECTIVE: We evaluated an inpatient transition consultation (ITC) for adolescents and young adults (AYAs) with chronic conditions and their caregivers admitted to the hospital to assess ITC content, evaluate how it addressed transition concerns, determine its impact, and identif...

Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study

Abstract Early cancer detection improves survival; however, most cancer types do not have guideline-recommended screening. We previously reported the first PATHFINDER study that established feasibility of cancer screening with a blood-based multi-cancer early detection (MCED) tes...

Bridging gaps in future healthcare professionals’ understanding of justice-related healthcare

The impact of mass incarceration extends beyond the isolated experiences of justice-involved individuals and has a reaching, multifactorial impact on the health of society. Healthcare providers must be prepared to treat patients who are returning from carceral facilities. Unfortu...

The Technology Dependence Index (TDI): Development and Validation in Neonatal and Pediatric Populations

The survival of infants and children with complex medical conditions continues to increase, underscoring the need to quantify technology dependence more effectively. Existing measures emphasize mortality risk and fail to capture the burden of ongoing technological support. To add...

Novel Antibodies for Managing Cachexia

Cachexia is a complex, multifactorial syndrome driven by anorexia and systemic inflammation, ultimately resulting in a catabolic state characterized by weight loss, decreased muscle mass, and impaired physical function. Many chronic comorbidities are implicated in the pathophysio...