Duke Cancer Institute

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Postoperative Opioid Use Prediction Calculator Performance in Patients Undergoing Gynecologic Surgery

Importance Postoperative opioid overprescription contributes to the opioid epidemic. Objective To expand and validate a gynecologic oncology–developed postoperative opioid use prediction calculator in a diverse surgical population and evaluate whether it could be modified for pre...

Evaluation of Intervention Strategies to Improve Follow-Up Colonoscopy After Abnormal FIT/FOBT Result

Importance Colorectal cancer is the second leading cause of cancer mortality worldwide. Early detection through screenings has been shown to improve morbidity and mortality. While fecal immunochemical test (FIT) or fecal occult blood test (FOBT) are established cost-effective scr...

Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis

Study Design Systematic Review. Objectives The objective of this study was to answer two questions: (1) Did the overall survival (OS) of patients with spinal metastatic renal cell carcinoma (mRCC) improve in publications from 2017 and afterwards compared to 2016 and before? (2) D...

Longitudinal evaluation of sleep disturbances in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Abstract Purpose The current study examines longitudinal changes in sleep disturbances and the risks they pose for new-onset health conditions in survivors of childhood cancer. Methods Five-year survivors ( N = 1081; median [range] age 50.0 [45.2–55.0] years) and siblings ( N = 2...