D’Or Institute for Research and Education

The Impact of PICU Diaries on Posttraumatic Stress Disorder and Psychological Distress in Parents of Critically Ill Children Admitted to PICUs: A Randomized Cluster Crossover Trial

OBJECTIVES: The study aimed to assess the effect of using diaries during hospitalization in a PICU on the occurrence of posttraumatic stress disorder (PTSD) and psychologic distress among family members of critically ill children. DESIGN: A two-arm, two-period, cluster-randomized...

Biomolecules under Pressure: Protein Phase Transitions from Folding to Misfolding, Aggregation, and Condensation

Abstract High hydrostatic pressure provides a unique and sensitive perturbation to protein structure, enabling direct measurement of volume changes associated with folding, misfolding, and assembly. Because pressure perturbs noncovalent forces while preserving covalent integrity,...

Circulating blood biomarkers after traumatic brain injury: A subanalysis of the biperiden phase III randomized, double‐blind clinical trial ( NCT01048138 )

OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of acquired epilepsy, death, and long-term disability, yet reliable biomarkers to predict chronic sequelae such as post-traumatic epilepsy (PTE) remain limited. We evaluated the associations between circulating blood biom...

Balance Between Order and Disorder: Quantum-Epigenetic Pathways for the Emergence and Continuous Evolution of Life

Abstract The scientific restlessness surrounding the question of what life is (expressed in the provocations of Feynman and Schrödinger) guides this review article by integrating physics, chemistry, and biology into a multidimensional and emergent approach to the origin, evolutio...

Albumin-based cationic nanoemulsion for Protoporphyrin IX delivery in normoxic and hypoxic conditions

Glioblastoma is one of the deadliest cancers in humans, but its treatment is limited by the difficulty drugs have in crossing the blood-brain barrier. Albumin-based nanomaterials have emerged as promising drug delivery systems for neurooncology applications, particularly for the...

Ultrasound-guided management of reversible diaphragmatic dysfunction after extubation in an infant with transient pectus excavatum: a case report

Abstract Background : Diaphragmatic dysfunction is a clinically relevant complication of invasive mechanical ventilation (IMV) in infants, associated with respiratory biomechanical immaturity and reduced muscle activation related to sedation and prolonged ventilatory support. Dia...

OA06-LBA01.7. Robotic Preservation of the Anterior Sac Suturing (PASS) Technique for GERD: Anatomical Rationale, Surgical Technique and Early Outcomes

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Hiatal hernia recurrence remains a major limitation of antireflux surgery, frequently originating at the anterior–lateral hiatus. Preservation of native anatomical structures may improve durabili...