Dongguan People’s Hospital

Association of one-stop administrative and logistics services with patient satisfaction in smart hospitals

This study aims to examine whether the quality of one-stop administrative and logistics services is associated with patient satisfaction in smart hospitals and identify indicators that may merit attention in service redesign. This multicenter cross-sectional study included 837 se...

Experimental evidence for NOG as a promoter of TGF-β/SMAD signaling in pancreatic cancer cells

Pancreatic adenocarcinoma (PAAD) is a common malignancy characterized by high mortality. TGF-β signaling has been implicated in tumor initiation and development. This study aimed to construct a prognostic model based on TGF-β pathway-related genes for patients with PAAD. PAAD sam...

Pan-African genomics of Pseudomonas aeruginosa highlights regional population structure and AMR stratification

Abstract Background Pseudomonas aeruginosa is a leading cause of life-threatening nosocomial infections and a World Health Organization "Priority 1" critical pathogen. Despite the escalation of global antimicrobial resistance (AMR), the genomic landscape of P. aeruginosa across A...

Plasma multi-omics signatures of the EAT-Lancet diet and associations with health outcomes

The EAT-Lancet diet aims to optimize human health and environmental sustainability, but the biological changes associated with this dietary pattern remain incompletely characterized. We aimed to identify plasma proteomic and metabolomic signatures associated with adherence to the...

Association of hydroxychloroquine use with pregnancy outcomes in euthyroid TPOAb-positive women with unexplained recurrent pregnancy loss: a retrospective cohort study

Recurrent pregnancy loss (RPL) is a multifactorial disease. Approximately 40–60% of cases remain unexplained and are classified as unexplained recurrent pregnancy loss (URPL). Thyroid autoimmunity (TAI), particularly thyroid peroxidase antibody (TPOAb) positivity, has been implic...

Immunogenetic determinants of influenza B virus susceptibility and vaccine response: current evidence, gaps, and future directions

Influenza B virus (IBV) remains an important but comparatively underexamined contributor to seasonal influenza burden, particularly in children, adolescents, and older adults. Although IBV lacks the broad animal reservoir and pandemic potential of influenza A virus, its epidemiol...

A practical nomogram for the early prediction of hemiplegic shoulder pain in stroke patients: a development and validation study

Abstract Objective To facilitate early clinical risk stratification for hemiplegic shoulder pain (HSP) after stroke, this study aimed to identify potential risk factors and develop a predictive nomogram. Methods This retrospective study included 450 inpatients with stroke admitte...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

Toxic epidermal necrolysis complicated by bronchiolitis obliterans in a child: a case report

Abstract Background Stevens‑Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that may be accompanied by multi‑organ involvement and high mortality. TEN complicated by bronchiolitis obliterans (BO) is extremely rare among children....

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA...

Associations of Illness Perception, Resignation Coping, and Social Support With Self‐Regulatory Fatigue in Patients With Type 2 Diabetes: A Cross‐Sectional Study

ABSTRACT Aims To examine the associations among illness perception, resignation coping, social support, and self‐regulatory fatigue (SRF) in patients with Type 2 diabetes mellitus. The study specifically explores whether resignation coping and social support exhibit indirect asso...

Serum S100A6, ICAM-1, and S100B and neurocognitive outcomes after pediatric tonsillectomy and adenoidectomy

To investigate the relationship between serum levels of S100 calcium-binding protein A6 (S100A6), intercellular adhesion molecule-1 (ICAM-1), and S100 calcium-binding protein B (S100B) and the development of postoperative delirium (POD) and postoperative cognitive dysfunction (PO...

Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank

There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were th...

Parents’ knowledge, attitude, and practice toward mouth breathing in children: a mediation analysis

This study aims to assess parents’ knowledge, attitude, and practice (KAP) regarding mouth breathing in children. This multicenter cross-sectional study was conducted from July to October 2024 among parents. A total of 1,966 valid responses were analyzed. Among the children, 1,07...

Pamiparib plus surufatinib with ctDNA monitoring in platinum-resistant ovarian cancer after PARP inhibitor progression: a phase Ib/II trial (POST-PARPi)

<title>Abstract</title> Background PARP inhibitors (PARPi) are standard front-line maintenance therapy for advanced ovarian cancer, but the efficacy of PARPi retreatment in later lines remains unclear. This phase Ib/II study evaluated the combination of pamiparib (a PARPi) and su...

Clinical value of hsa_circ_0003254 in postmenopausal osteoporosis and its role in the progression of osteoporosis

Objective Circular RNAs (circRNAs) are important regulators of human disease, yet their specific mechanistic role in postmenopausal osteoporosis (PMOP) remains unclear. This study aimed to investigate the expression pattern, diagnostic value, and biological function of hsa_circ_0...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Single‐Molecule Real‐Time Sequencing Reveals Hidden Diversity and Corrects Misdiagnosis in α‐Thalassemia

ABSTRACT Objectives Conventional methods for α‐thalassemia gene diagnosis, such as Gap‐PCR, are primarily designed for common deletions. However, their limitations in detecting complex rearrangements that maintain the total copy number of α‐globin genes can lead to misdiagnosis,...

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...

Multi-algorithm consensus clustering identifies four subphenotypes in sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury (SA-AKI) is a highly heterogeneous syndrome with variable clinical trajectories and outcomes. Conventional staging systems, such as KDIGO, fail to capture this heterogeneity, limiting risk stratification and personalized management. We aimed...