Dongguan People’s Hospital

Early-life recurrent antibiotic use and risks of adult kidney cancer and sex-specific cancers: a prospective cohort study in the UK Biobank

There is little evidence about the associations of long-term or recurrent antibiotics use (LRAU) during early life with cancer risk. Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank (UKB). The main outcomes were th...

Parents’ knowledge, attitude, and practice toward mouth breathing in children: a mediation analysis

This study aims to assess parents’ knowledge, attitude, and practice (KAP) regarding mouth breathing in children. This multicenter cross-sectional study was conducted from July to October 2024 among parents. A total of 1,966 valid responses were analyzed. Among the children, 1,07...

Pamiparib plus surufatinib with ctDNA monitoring in platinum-resistant ovarian cancer after PARP inhibitor progression: a phase Ib/II trial (POST-PARPi)

<title>Abstract</title> Background PARP inhibitors (PARPi) are standard front-line maintenance therapy for advanced ovarian cancer, but the efficacy of PARPi retreatment in later lines remains unclear. This phase Ib/II study evaluated the combination of pamiparib (a PARPi) and su...

Clinical value of hsa_circ_0003254 in postmenopausal osteoporosis and its role in the progression of osteoporosis

Objective Circular RNAs (circRNAs) are important regulators of human disease, yet their specific mechanistic role in postmenopausal osteoporosis (PMOP) remains unclear. This study aimed to investigate the expression pattern, diagnostic value, and biological function of hsa_circ_0...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Single‐Molecule Real‐Time Sequencing Reveals Hidden Diversity and Corrects Misdiagnosis in α‐Thalassemia

ABSTRACT Objectives Conventional methods for α‐thalassemia gene diagnosis, such as Gap‐PCR, are primarily designed for common deletions. However, their limitations in detecting complex rearrangements that maintain the total copy number of α‐globin genes can lead to misdiagnosis,...

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...

Multi-algorithm consensus clustering identifies four subphenotypes in sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury (SA-AKI) is a highly heterogeneous syndrome with variable clinical trajectories and outcomes. Conventional staging systems, such as KDIGO, fail to capture this heterogeneity, limiting risk stratification and personalized management. We aimed...

Ferroptosis as a central mechanism in inhaled tris(1-chloro-iso-propyl) phosphate (TCIPP)-induced lung injury: Associations with pyroptosis and mitochondrial dynamic imbalance

), along with elevated ferroptosis markers (p53, Transferrin Receptor 1 (TFR1)) and reduced FTH1 levels following TCIPP inhalation. These effects were counteracted by the ferroptosis inhibitor Fer‑1 (0.8 mg/kg), which also attenuated pathological damage, ROS accumulation, and NLR...

A scoping review of patient self-disclosure assessment tools in healthcare settings

To conduct a scoping review of patient self-disclosure assessment tools both domestically and internationally, and to provide a reference for the selection of clinical assessment tools or related research. This scoping review was conducted in accordance with the methodological fr...