Don Carlo Gnocchi Foundation

A consortium-driven framework for biomarker prioritization in the HEBE aging study

Abstract Aging is a complex biological process influenced by chronic low-grade inflammation, oxidative stress, and metabolic dysregulation, collectively termed inflammaging. The HEBE (Healthy aging versus inflamm-aging: the role of physical Exercise in modulating the Biomarkers o...

The Italian Nanomedicine Platform (INP): national integration within the European nanomedicine ecosystem

Italy’s nanomedicine expertise has long developed in fragmented manner, with limited coordination across academia, clinical institutions, industry and regulatory bodies. The Italian Nanomedicine Platform (INP) was established to integrate discovery, preclinical validation, regula...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

Assistive technologies (lumbar supports and other devices) for treating chronic low back pain

RATIONALE: Low back pain (LBP) is a major global health problem. It is the most common cause of activity limitation amongst individuals younger than 45 years, and one of the most frequent reasons for visits to a doctor. The 2019 Global Burden of Disease study named LBP as the lea...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

From male caduco to altered consciousness: two Medici recipes through the lens of modern consciousness science

This article examines two therapeutic recipes from the collection of Anna Maria Luisa de' Medici (1667-1743), the last Medici princess: the Polvere da Infantiglioli against the falling sickness (male caduco) and a preparation of amber essence. Together, they provide a case study...

Expiratory phase lung mechanics in late-onset Pompe disease: a multicenter study using oscillometry to identify specific breathing abnormalities

Abstract Introduction In late-onset Pompe disease (LOPD), muscle weakness causes restrictive lung impairment. In murine models, glycogen deposition in lung parenchyma suggests additional causes for restriction that remain poorly understood. We investigated whether oscillometry de...

Co-Colonization by Multiple Multidrug-Resistant Organisms in a Long-Term Neurorehabilitation Setting: A Case Report

Neurorehabilitation units (NRUs) are long-term care settings associated with multiple risk factors for carriage and infection by multidrug-resistant organisms (MDROs), including prolonged hospitalization, the use of invasive medical devices, high antibiotic exposure, and multiple...

Surface Functionalization of Small Extracellular VesiclesDerived from Caco-2 and HEK293T Cells in the Neutralizationof Shiga Toxin 1 Subunit B

Abstract Shiga toxins (Stx) are key virulence factors of Shiga toxin-producing Escherichia coli (STEC), which are responsible for severe foodborne infections that can progress to hemolytic-uremic syndrome (HUS). Currently, no specific antitoxin therapies are available. In this st...