Institution
Doheny Eye Institute
Recent research
- Health & Medicine
Blindness After Facial Filler: An Alternative Theory
Facial fillers are widely regarded as a safe and effective method for cosmetic enhancement, with common adverse effects including bruising, swelling, and tenderness. Rarely, however, vascular complications can occur, resulting in severe outcomes such as sudden blindness. The clas...
- Health & MedicineOpen access
Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema
This analysis evaluated the impact of early intraretinal fluid (IRF) reduction on long-term visual outcomes in patients with diabetic macular edema (DME). This was a treatment-agnostic, post hoc analysis of pooled data from patients with DME in YOSEMITE/RHINE (NCT03622580/NCT0362...
- Health & Medicine
Why Metrics Matter in Thyroid Eye Disease
Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the clinical me...
- Health & MedicineOpen access
Optic Disc and Retinal Strain Due to Vertical Duction
Purpose: To compare two-dimensional optic disc and retinal vessel strains due to vertical versus horizontal eye rotations in younger and older subjects using confocal scanning laser ophthalmoscopy (cSLO). Methods: In a younger subject group (n = 10; range, 18-39 years; mean age ±...
- Health & MedicineOpen access
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
ABSTRACT Synaptic dysfunction is a major driver of cognitive decline in Alzheimer's disease (AD), yet its extent and molecular basis in the retina remain poorly defined. We integrated postmortem retinal and matched brain histopathology with ultrastructural, proteomic, biochemical...
- Health & Medicine
Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...
- Health & Medicine
PURPOSE: We evaluate the Clínica Esperanza Ophthalmology Service, a free service for uninsured patients in southern New England. METHODS: The service operates monthly under a novel clinic-within-a-clinic model, existing as a subsidiary of a local free clinic. A mixed-methods prog...
PubMed2026-08-010 citations - Health & MedicineOpen access
Purpose: To evaluate the temporal behavior and relative variability of a margin-based metric, lesion front displacement, for quantifying geographic atrophy (GA) progression secondary to age-related macular degeneration and to compare its performance with conventional metrics. Met...