DKFZ-ZMBH Alliance

Real‐World Experience With Multimodal Treatment of Resectable Stage II – III Non‐Small Cell Lung Cancer: A Single Institutional Analysis

ABSTRACT Neoadjuvant therapy has recently become an integral component of multimodal treatment for resectable lung cancer. However, real‐world data on perioperative morbidity and treatment adherence remain limited. This study aimed to assess the feasibility and safety of differen...

A single-amino-acid cleavage controls global mitochondrial complex integrity

Abstract Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins. Defects in this maturation step are implicated in disease, yet the functional impact in humans remains unclear. Here we show that the intermediate cleaving peptidase ICP55...

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Endolysosomal dysfunction is a hallmark of Alzheimer’s disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregatio...

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

BACKGROUND AND PURPOSE: Myeloid cell leukaemia-1 (MCL-1) is an essential anti-apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL-1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardioto...