Division of Parasitic Diseases and Malaria

A Plasmodium knowlesi A1-H.1 transcriptome time course focusing on the late asexual blood stages

Abstract Background The zoonotic parasite Plasmodium knowlesi is closely related to Plasmodium vivax , the second leading cause of human malaria. P. knowlesi line A1-H.1 can be maintained in human erythrocytes and is an experimental model for P. vivax biology. We present the firs...

Evaluation of the clinical performance of two new onchocerciasis rapid diagnostic tests in districts targeted for elimination in Ghana

Current diagnostic methods for onchocerciasis lack sufficient utility, sensitivity or specificity. Two new lateral flow assays developed by Bioaster and Global Access Diagnostics (BA/GADx) and Drugs and Diagnostics for Tropical Diseases (DDTD) multi-antigen test Biplex Version C...

Phenotypic insecticide resistance in Jamaican Aedes spp. and resistance-associated transcripts in Aedes aegypti

Insecticide resistance in mosquito vectors threatens control of vector-borne diseases across the Caribbean. In Jamaica, resistance in Aedes aegypti has been documented in both urban and rural settings, while susceptibility of other potential vector species and transcriptional res...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Streamlined durability monitoring of DuraNet® Plus and Interceptor® G2 insecticide-treated nets in Northern Region, Cameroon: assessment results in two sites from 2022 to 2025

Abstract Background Insecticide-treated nets (ITNs) are a critical vector control and malaria prevention tool. Routine monitoring of ITN physical and chemical durability is key to assessing their performance under real-world conditions. A streamlined ITN durability monitoring met...