Discovery Centre

Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody–Mediated Rejection

Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...

Establishment of an in vitro aerobic bacterial community as a model of the human lung microbiome

ABSTRACT The human lung microbiome is increasingly recognized as a key player in drug metabolism, yet it remains largely understudied. To replicate this complex physiological environment in a controlled setting, we developed a simplified artificial lung microbiome model composed...