Dhahran Health Center

LC–MS/MS Method for Simultaneous Quantification of Zolpidem, Zopiclone, and Their Metabolites in Human Urine and Its Pharmacokinetic Application

ABSTRACT Zolpidem (Z1) and zopiclone (Z2) are widely prescribed for insomnia; but their misuse in drug‐facilitated crimes presents significant forensic and clinical challenges. This study aimed to develop and validate a simple and sensitive LC–MS/MS method, coupled with dispersiv...

Bilateral sclerocornea in an infant with molecularly confirmed Van den Ende–Gupta syndrome due to a recurrent SCARF2 founder variant: a case report and review of ophthalmic manifestations

PURPOSE: Van den Ende-Gupta syndrome (VDEGS) is a rare autosomal recessive disorder caused by biallelic variants and characterized by blepharophimosis, arachnodactyly, congenital joint contractures, and a recognizable craniofacial phenotype, with normal growth and intelligence. T...