Detroit Medical Center

A Blueprint for Developing a Concentration in Ambulatory Care Within the PharmD Curriculum

ABSTRACT The US healthcare system is grappling with significant challenges, notably a shortage of primary care providers. Ambulatory care pharmacists are increasingly recognized as vital contributors to addressing these challenges. The Accreditation Council for Pharmacy Education...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

Long-Term Complications and Secondary Procedures After Open Reduction and Internal Fixation of Ankle Fractures: A Descriptive Epidemiologic Study of Over 50,000 Patients.

Background Ankle fractures account for ~10% of fractures, ~40% treated operatively, yet absolute long-horizon complication and secondary-procedure estimates by fracture pattern and comorbidity remain limited. Prior series generally left decedents in the denominator as though stil...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

Microbiome-Based Therapeutics in Oncology: Expanding Indications Beyond C. difficile

The intestinal microbiome has emerged as a clinically significant modulator of outcomes across multiple domains of cancer care. In hematopoietic stem cell transplantation (HSCT), loss of microbial diversity and depletion of short-chain fatty acid-producing commensals are independ...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis

In the treatment of atrial fibrillation (AF), cryoballoon ablation (CBA) is associated with a high incidence of pulmonary vein reconnection, potentially limiting long-term efficacy. Pulsed field ablation (PFA) has emerged as a promising alternative with the potential for improved...

Emergency department management of postthrombolysis intracranial hemorrhage.

Intracranial hemorrhage following intravenous thrombolytic therapy most commonly occurs within 12 hours of administration. Because many patients remain in the emergency department during this period, a structured, time-sensitive approach to recognition and management is critical....