Desert Regional Medical Center

Immune checkpoint inhibitors for African people living with HIV: T-cell exhaustion, endemic co-infections, and the oncology trial gap

Immune checkpoint inhibitors (ICIs) have fundamentally transformed modern oncology by unleashing the body’s anti-tumor immunity, yet people living with HIV (PLWH) were systematically excluded from the pivotal registration trials. This evidence gap is especially consequential in s...

Geriatric Substance Use: A Rising Burden for Trauma Systems

Background Substance use among geriatric populations is rising rapidly, posing new challenges for trauma systems. Older adults are particularly vulnerable due to comorbidities and physiologic decline, yet the impact of prehospital substance use in this population after trauma rem...