Department of Medical Sciences

Vancomycin therapeutic drug monitoring: trends and seasonal patterns

Vancomycin is widely used for serious Gram-positive infections, but its narrow therapeutic index necessitates therapeutic drug monitoring (TDM). Over recent decades, monitoring has shifted from trough-based to AUC-guided dosing. This study investigated long-term trends in vancomy...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Predictors of Severe Course in Odontogenic Cervicofacial Infections: A Prospective Multicenter Cohort Study

Background: Odontogenic cervicofacial infections are prevalent and can progress to life-threatening conditions, imposing a substantial burden on both patients and healthcare systems. The present study evaluated the association of presentation delay and comorbidities with clinical...

Cardiovascular and thromboembolic risk in anti-neutrophil cytoplasmic antibody-associated vasculitis: a nationwide matched cohort study by disease, sex, and familial risk

OBJECTIVES: To investigate influence of sex, diagnosis (granulomatosis with polyangiitis (GPA) vs. microscopic polyangiitis (MPA)), and familial factors on cardiovascular disease and thromboembolism (CVD-TE) risk in patients with anti-neutrophil cytoplasmic antibody-associated va...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis

ABSTRACT Objective The interferon (IFN) system is activated in systemic sclerosis (SSc), but the driving mechanisms remain unclear. We asked whether type I and III IFN responses to Toll-like receptor (TLR)-7/8/9 stimulation of leukocytes from patients with SSc differ from healthy...

MORPHOLOGICAL AND MICROBIOLOGICAL CHANGES IN THE INTESTINAL TRACT FOLLOWING EXPERIMENTAL CHOLECYSTECTOMY

Gallstone disease (GLD) is a disease of the hepatobiliary system, characterized by the formation of changes in the internal bile ducts of the liver, the common bile duct, and the gallbladder. Gallstone disease, according to most statistical analyses, is more common in young and m...

Quantification of Urinary NGAL Using Volumetric Dried Urine Sampling

Objective: To evaluate the measurement of urinary neutrophil gelatinase-associated lipocalin (NGAL) from dried urine samples collected using Capitainer qDBS discs compared with liquid urine. Methods: Eighty urine samples from children aged 0–18 years were analysed. NGAL concentra...