Department of Medical Sciences

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

Intraoperative Adverse Events in Robot-assisted Minimally Invasive Esophagectomy (RAMIE)

Objective: Assess the incidence and management of intraoperative adverse events (IAEs) during robot-assisted minimally invasive esophagectomy (RAMIE) and evaluate their impact on postoperative outcomes. Background: IAEs are an inherent component of surgical practice and owing to...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Real-World Effectiveness of Secukinumab in Congenital Ichthyoses: A Retrospective Monocentric Case Series

Background/Objectives: Congenital ichthyoses (CI) are inherited disorders of keratinization characterized by epidermal barrier dysfunction, abnormal desquamation, and variable degrees of inflammation. Increasing evidence suggests a role for IL-23/Th17-mediated immune dysregulatio...

Integrated Strategy for Low-FODMAP Bread Formulation: Selection of Wheat Flours and Microbial Starter

Irritable bowel syndrome (IBS) symptoms are often triggered by the consumption of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), which are widely found in cereal-based foods, dairy products, fruits, legumes, and vegetables. Among these, cerea...

Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents

Importance Puberty is a critical window for bone mass acquisition, determining lifelong fracture risk. Gonadotropin-releasing hormone agonist (GnRHa)–based pubertal suppression followed by gender-affirming hormone therapy (GAHT) is increasingly used in transgender and gender-dive...

Electrocortical activity across postural conditions during real-world sea navigation in mariners with motion sickness susceptibility

Abstract Work and sports activities can be affected by motion sickness in unstable environments, such as at sea, with potential consequences for performance. Central manifestations of motion sickness have been reported in simulator studies, including changes in cortical oscillati...