Department of Medical Sciences

Sustainable lesson study in Italian secondary education: insights from a lesson on the regression line

Purpose The purpose of this paper is to present the adapted model of lesson study implemented in an Italian upper secondary school and sustained over the past seven years. To illustrate and reflect on this approach, the paper reports an example of lesson study activity carried ou...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

Real-world Italian experience with asciminib in chronic myeloid leukaemia–chronic phase: case series and drug profile overview

Abstract Asciminib selectively targets the myristoyl pocket of ABL1, offering high specificity and a potentially improved safety profile. Its efficacy has been demonstrated in both clinical trials and real-world settings, including heavily pretreated patients and those with T315I...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

An Alternative Test to Evaluate the Assistance Provided by Back-Support Exoskeletons: A Pilot Study

OCCUPATIONAL APPLICATIONSThe test proposed in this study, assimilable to a maximal isometric mid-thigh pull, appears to detect the acute assistance provided by the exoskeleton, expressed as the difference in performance with and without donning the device; the test can be perform...

“Uroboros” circle: a multilevel study on leader–follower and follower–leader crossover

Purpose The literature on the crossover theory (Westman, 2001) typically focuses on how leaders influence followers’ well-being by exchanging psychological states and resources (Hobfoll et al., 2018). However, the role of followers in influencing leaders’ well-being has been less...

Posttherapy [18F]FDOPA PET Findings in an Anaplastic Pleomorphic Xanthoastrocytoma With a BRAF V600E Mutation

Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare pediatric high-grade glioma (pHGG). We report a 10-year-old boy with a left temporal APXA harboring a BRAF V600E mutation, who presented with generalized tonic–clonic seizures 3–4 times weekly, treated with combined BRAF a...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Dissecting Cellulitis and Hidradenitis Suppurativa: Two Diseases or One Follicular‐Occlusion Spectrum?

ABSTRACT Dissecting cellulitis of the scalp (DC) and hidradenitis suppurativa (HS) share follicular occlusion, rupture, suppuration, tunnel formation, and scarring, yet are usually classified as separate diseases. Whether DC represents a site‐modified scalp phenotype of the same...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

Intraoperative Adverse Events in Robot-assisted Minimally Invasive Esophagectomy (RAMIE)

Objective: Assess the incidence and management of intraoperative adverse events (IAEs) during robot-assisted minimally invasive esophagectomy (RAMIE) and evaluate their impact on postoperative outcomes. Background: IAEs are an inherent component of surgical practice and owing to...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Real-World Effectiveness of Secukinumab in Congenital Ichthyoses: A Retrospective Monocentric Case Series

Background/Objectives: Congenital ichthyoses (CI) are inherited disorders of keratinization characterized by epidermal barrier dysfunction, abnormal desquamation, and variable degrees of inflammation. Increasing evidence suggests a role for IL-23/Th17-mediated immune dysregulatio...

Integrated Strategy for Low-FODMAP Bread Formulation: Selection of Wheat Flours and Microbial Starter

Irritable bowel syndrome (IBS) symptoms are often triggered by the consumption of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), which are widely found in cereal-based foods, dairy products, fruits, legumes, and vegetables. Among these, cerea...

Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents

Importance Puberty is a critical window for bone mass acquisition, determining lifelong fracture risk. Gonadotropin-releasing hormone agonist (GnRHa)–based pubertal suppression followed by gender-affirming hormone therapy (GAHT) is increasingly used in transgender and gender-dive...

Electrocortical activity across postural conditions during real-world sea navigation in mariners with motion sickness susceptibility

Abstract Work and sports activities can be affected by motion sickness in unstable environments, such as at sea, with potential consequences for performance. Central manifestations of motion sickness have been reported in simulator studies, including changes in cortical oscillati...