Department of Health and Human Services

Residential proximity to intensive animal agriculture associates with increased prevalence of antimicrobial resistance in homes

BACKGROUND: Antimicrobial resistance (AMR), a global public health threat, affects rural communities disproportionately due to their unique regional exposures, including proximity to animal feeding operations (AFOs), a source of AMR genes. OBJECTIVE: We evaluated residential prox...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Associations between a mixture of trace elements and bladder cancer occurrence

Background: The association between trace elements and bladder cancer risk is not well understood. Individuals are typically exposed to a mixture of multiple elements simultaneously, such as through water pollution or diet. While previous studies have explored associations betwee...