Department of Embryology

Immunohistochemical investigation of suprabasin, isthmin-1, and podocalyxin immunoreactivity in basal cell carcinoma and trichoblastoma/trichoepithelioma

Objective Basal cell carcinoma (BCC) and trichoblastoma/trichoepithelioma (TB/TE) are skin tumors that may exhibit similar histopathological features. This study aimed to examine the immunoreactivity of suprabasin (SBSN), isthmin-1 (ISM-1), and podocalyxin (PODXL) BCC and TB/TE,...

Liposome supplementation enhances host metabolism in a model symbiotic cnidarian

Abstract Stable cnidarian–dinoflagellate symbioses provide the trophic foundation of coral reef ecosystems. Understanding nutrient exchange underpinning this symbiosis, and the need for interventions to improve coral health via aquaculture, grow increasingly urgent as reefs face...

Pregnancy establishment in cattle without embryonic interferon tau

In ruminants, embryonic interferon tau (IFNT) is widely considered the indispensable signal for maternal recognition of pregnancy, driving endometrial gene expression to prevent luteolysis. However, this canonical paradigm has never been directly tested using genomic loss-of-func...

Comparative clinical and reproductive outcomes following non-invasive versus biopsy-based preimplantation genetic testing for aneuploidy: a multicentric cohort study

Abstract Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) is emerging as a newer technology alongside conventional trophectoderm biopsy-based PGT-A, aiming to avoid embryo biopsy while enabling genetic assessment through analysis of cell-free DNA. However, it...

Tissue engineering scaffolds for the spinal cord: recent advances and future prospects

Spinal cord tissue engineering scaffolds represent a highly promising option for the treatment and repair of spinal cord injury (SCI). They have a wide range of potential applications and, as essential biomaterial carriers, can restore the multifunctional microenvironment. Since...

Reconstitution of lamin assembly on nuclear pore complex-containing membranes

Intermediate filaments called lamins line the metazoan nuclear envelope and organize the nucleus and genome. Unlike actin and microtubules, purified intermediate filament proteins assemble into non-physiological structures, making it difficult to connect lamin functions to their...

Enhancing Oligodendrogenesis Rescues Chronic Stress‐Induced Behavioral Disorders Involving Neuronal and Synaptic Reorganization

ABSTRACT Chronic stress induces psychiatric disorders, including depression and anxiety, yet effective therapies remain limited. Myelin in adult brains undergoes dynamic remodeling through oligodendrocyte precursor cells (OPCs) differentiation into oligodendrocytes (OLs) and the...

Protective Effect of Ozone on Liver Ischemia–Reperfusion (I/R) Injury in Streptozotocin-Induced Diabetic Rats

The aim of this study was to investigate the effects of ozone therapy on the liver, one of the organs most affected by ischemia–reperfusion damage in people with diabetes. Thirty male Wistar albino rats were used in this study. The rats were randomly divided into four groups: the...

A 14-day repeated dose oral toxicity assessment of the aqueous-ethanolic extract of Schouwia purpurea in female Wistar albino mice

Schouwia purpurea (Family: Brassicaceae) S. purpurea is a wild medicinal plant traditionally used for treating gastrointestinal, inflammatory, and infectious disorders in arid regions of North Africa. Despite its ethnomedicinal importance, little is known about its systemic safet...

Protective or Therapeutic Effect of Exosomes Isolated From Mesenchymal Stem Cells on Cisplatin‐Induced Ovarian Damage

ABSTRACT Cisplatin (Cis), an index drug with the greatest gonadotoxic potential, affects both primordial follicles and developing follicles (pre‐antral) in vivo. Mesenchymal stem cell‐derived exosomes accelerate cell proliferation and wound healing. Exosomes have been shown to in...