Department of Biotechnology

Integrative DNA barcoding and multimethod species delimitation reveal marker performance in the genus Ficus L. (Moraceae)

Accurate delimitation of species is fundamental for understanding biodiversity, evolutionary history, and conservation priorities, particularly in taxonomically challenging genera such as Ficus . This study systematically evaluates the performance of three single locus barcodes (...

Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in MTAP-Null Non-Small Cell Lung Cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) is a synthetic lethal target in methylthioadenosine phosphorylase-deleted (MTAP-null) cancers. Second-generation MTA-cooperative PRMT5 inhibitors preferentially target MTAP-null cells while largely sparing MTAP-wildtype (MTAP-...

Unlocking the potential of agro-industrial wastes as valorizable substrates for bacterial carotenoid production – A comprehensive review

The sustainable production of valorizable bacterial metabolites, such as carotenoids, using inexpensive substrates or waste materials, including agrowaste, faces several challenges. Research in this area needs to gain momentum to achieve green goals for a better tomorrow. Efficie...

Knowledge-guided reinforcement learning for self-adaptive software engineering and multi-objective quality optimization

The current software engineering field is experiencing growing pressures due to the complexity of software systems, rapidly changing requirements, and high-quality expectations in a dynamic environment. Conventional development and quality assurance strategies are usually inflexi...