Department of Biotechnology

Immunoinformatics-based design and in silico evaluation of a multi-epitope vaccine candidate against Naegleria fowleri

Primary amoebic meningoencephalitis (PAM) is caused by Naegleria fowleri , a free-living amoeba. It is a fatal infection with more than 95% mortality rate. Even though several combinations of antimicrobial agents were used to treat the condition, the overall survival remains poor...

RNA-guided transposases: the successors to CRISPR

CRISPR undoubtedly transformed genome editing, but it left two crucial problems unsolved. Cas nucleases cut the chromosome and leave the cell to repair the break, an error-prone process that is inefficient for installing new DNA, and Cas9 is large relative to the cargo that viral...

Environmental Pollution in India: Causes, Effects, And Sustainable Solutions

Abstract Environmental pollution has become one of the most significant geographical and environmental challenges facing India. Rapid industrialization, urbanization, population growth, and the overexploitation of natural resources have resulted in serious environmental degradati...

Environmental Pollution in India: Causes, Effects, And Sustainable Solutions

Abstract Environmental pollution has become one of the most significant geographical and environmental challenges facing India. Rapid industrialization, urbanization, population growth, and the overexploitation of natural resources have resulted in serious environmental degradati...

Environmental Pollution in India: Causes, Effects, And Sustainable Solutions

Abstract Environmental pollution has become one of the most significant geographical and environmental challenges facing India. Rapid industrialization, urbanization, population growth, and the overexploitation of natural resources have resulted in serious environmental degradati...

Environmental Pollution in India: Causes, Effects, And Sustainable Solutions

Abstract Environmental pollution has become one of the most significant geographical and environmental challenges facing India. Rapid industrialization, urbanization, population growth, and the overexploitation of natural resources have resulted in serious environmental degradati...

Environmental Pollution in India: Causes, Effects, And Sustainable Solutions

Abstract Environmental pollution has become one of the most significant geographical and environmental challenges facing India. Rapid industrialization, urbanization, population growth, and the overexploitation of natural resources have resulted in serious environmental degradati...

Electrochemical properties of neodymium-doped vanadium oxide nanoparticles in supercapacitor applications

Pure V2O5 and Nd3+-doped V2O5 nanoparticles were synthesized by the co-precipitation method and investigated as supercapacitor electrode materials. XRD confirmed the orthorhombic crystal structure, while FTIR, PL, and morphological analyses revealed structural modifications induc...

Integrative DNA barcoding and multimethod species delimitation reveal marker performance in the genus Ficus L. (Moraceae)

Accurate delimitation of species is fundamental for understanding biodiversity, evolutionary history, and conservation priorities, particularly in taxonomically challenging genera such as Ficus . This study systematically evaluates the performance of three single locus barcodes (...

Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in MTAP-Null Non-Small Cell Lung Cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) is a synthetic lethal target in methylthioadenosine phosphorylase-deleted (MTAP-null) cancers. Second-generation MTA-cooperative PRMT5 inhibitors preferentially target MTAP-null cells while largely sparing MTAP-wildtype (MTAP-...

Unlocking the potential of agro-industrial wastes as valorizable substrates for bacterial carotenoid production – A comprehensive review

The sustainable production of valorizable bacterial metabolites, such as carotenoids, using inexpensive substrates or waste materials, including agrowaste, faces several challenges. Research in this area needs to gain momentum to achieve green goals for a better tomorrow. Efficie...

Knowledge-guided reinforcement learning for self-adaptive software engineering and multi-objective quality optimization

The current software engineering field is experiencing growing pressures due to the complexity of software systems, rapidly changing requirements, and high-quality expectations in a dynamic environment. Conventional development and quality assurance strategies are usually inflexi...